Peroxisome proliferator-activated receptor γ: The more the merrier?

C. A. Argmann, T. A. Cock, Johan Auwerx

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


The consequence of activating the nuclear hormone receptor, peroxisome proliferator-activated receptor gamma (PPARγ), which coordinates adipocyte differentiation, validates the concept, 'you are what you eat'. Excessive caloric intake leads to fat formation if the energy from these nutrients is not expended. However, this evolutionary adaptation to store energy in fat, which can be released under the form of fatty acids, potent PPARγ agonists, has become a disadvantage in today's affluent society as it results in numerous metabolic imbalances, collectively known as the metabolic syndrome. With the surge of human and genetic studies on PPARγ function, the limitations to the benefits of PPARγ signalling have been realized. It is now evident that the most effective strategy for resetting the balance of this thrifty gene is through its modulation rather than full activation, with the goal to improve glucose homeostasis while preventing adipogenesis. Finally, as more PPARγ targeted pathways are revealed such as bone homeostasis, atherosclerosis and longevity, it is most certain that the PPARγ thrifty gene hypothesis will evolve to incorporate these.

Original languageEnglish
Pages (from-to)82-92
Number of pages11
JournalEuropean Journal of Clinical Investigation
Issue number2
StatePublished - Feb 2005
Externally publishedYes


  • Atherosclerosis
  • Longevity and bone
  • Metabolism
  • Mouse models
  • PPARγ


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