Peripheral vascular disease evaluated with reduced-dose gadolinium- enhanced MR angiography

Neil M. Rofsky, Glyn Johnson, Mark A. Adelman, Robert J. Rosen, Glenn A. Krinsky, Jeffrey C. Weinreb

Research output: Contribution to journalArticlepeer-review

149 Scopus citations


PURPOSE: To demonstrate the utility of low-dose gadolinium-enhanced magnetic resonance (MR) angiography of two consecutive anatomic areas for assessment of peripheral vascular disease. MATERIALS AND METHODS: Fifteen patients underwent gadolinium-enhanced MR angiography for evaluation of lower extremity peripheral vascular disease after conventional digital subtraction angiography (DSA). MR angiography was performed with three-dimensional coronal gradient-echo acquisitions before and during administration of gadopentetate dimeglumine. Two separate, contiguous areas were studied with separate doses of 0.075 and 0.1 mmol/kg gadopentetate dimeglumine. MR angiography findings were compared with DSA findings; DSA was the standard of reference. Treatment options were determined first with MR angiograms and then with DSA images. RESULTS: For distinguishing greater than 50% stenosis from 50% or less stenosis, gadolinium-enhanced MR angiography yielded a sensitivity of 97%, a specificity of 96%, and an accuracy of 97%. In 146 (97%) of 150 anatomic segments, there was essential or total agreement on treatments determined with MR angiography and DSA. In two cases (one case of vascular stent placement and one case of surgical anastomosis), extent of disease was overestimated with MR angiography. The MR study of one infrapopliteal area was insufficient for evaluation. CONCLUSION: Accurate gadolinium-enhanced MR angiography of multiple peripheral vascular areas of the lower extremities can be performed in most patients with less than 0.2 mmol/kg contrast material.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
Issue number1
StatePublished - Oct 1997
Externally publishedYes


  • Angiography, comparative studies
  • Arteries, extremities
  • Arteries, stenosis or obstruction
  • Gadolinium
  • Magnetic resonance (MR), comparative studies
  • Magnetic resonance (MR), vascular studies


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