Peripheral markers of catecholamine metabolism among workers occupationally exposed to manganese (Mn)

Audrey Smargiassi; Donna Mergler; Enrico Bergamaschi; Maria Vittoria Vetton; Roberto Lucchini; Pietro Apostoli

doi:10.1016/0378-4274(95)03314-9

Peripheral markers of catecholamine metabolism among workers occupationally exposed to manganese (Mn)

Audrey Smargiassi
, Donna Mergler
, Enrico Bergamaschi
, Maria Vittoria Vetton
, Roberto Lucchini
, Pietro Apostoli

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

In a preliminary study of 11 men randomly selected in a ferro-alloy plant and of 15 control subjects, platelet monoamine oxidase (MAO) and serum dopamine β-hydroxylase (DBH) activities were measured. A tendency towards lower MAO-B activity in the exposed workers as compared to control subjects (t = 1.95; P = 0.06) was found whereas DBH activity was similar. In the exposed group, a dose-effect relationship was noted between a manganese (Mn) cumulative exposure index (CEI) and DBH activity (R² = 0.40, P < 0.05). Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Owing to the limited sample size, these findings should be confirmed by further epidemiological and experimental studies.

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Toxicology Letters
Volume	77
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-4274(95)03314-9
State	Published - May 1995
Externally published	Yes

Keywords

Catecholamine metabolism
Mn
Peripheral markers

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10.1016/0378-4274(95)03314-9

Cite this

@article{98b33737b8a3473a81b03808ee4b5dc8,

title = "Peripheral markers of catecholamine metabolism among workers occupationally exposed to manganese (Mn)",

abstract = "In a preliminary study of 11 men randomly selected in a ferro-alloy plant and of 15 control subjects, platelet monoamine oxidase (MAO) and serum dopamine β-hydroxylase (DBH) activities were measured. A tendency towards lower MAO-B activity in the exposed workers as compared to control subjects (t = 1.95; P = 0.06) was found whereas DBH activity was similar. In the exposed group, a dose-effect relationship was noted between a manganese (Mn) cumulative exposure index (CEI) and DBH activity (R2 = 0.40, P < 0.05). Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Owing to the limited sample size, these findings should be confirmed by further epidemiological and experimental studies.",

keywords = "Catecholamine metabolism, Mn, Peripheral markers",

author = "Audrey Smargiassi and Donna Mergler and Enrico Bergamaschi and Vetton, \{Maria Vittoria\} and Roberto Lucchini and Pietro Apostoli",

note = "Funding Information: This work wass upportedb y the Commissiono f the European Communities STEP-CT9 1-O1 48 (DTEE) and by the National Sciences and EngineeringR esearchC ouncil of Canadas cholar-ship.W e are very gratefult o Fabrice Larribe and Antonio Mutti for encouragemenatn d advice.",

year = "1995",

month = may,

doi = "10.1016/0378-4274(95)03314-9",

language = "English",

volume = "77",

pages = "329--333",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Peripheral markers of catecholamine metabolism among workers occupationally exposed to manganese (Mn)

AU - Smargiassi, Audrey

AU - Mergler, Donna

AU - Bergamaschi, Enrico

AU - Vetton, Maria Vittoria

AU - Lucchini, Roberto

AU - Apostoli, Pietro

N1 - Funding Information: This work wass upportedb y the Commissiono f the European Communities STEP-CT9 1-O1 48 (DTEE) and by the National Sciences and EngineeringR esearchC ouncil of Canadas cholar-ship.W e are very gratefult o Fabrice Larribe and Antonio Mutti for encouragemenatn d advice.

PY - 1995/5

Y1 - 1995/5

N2 - In a preliminary study of 11 men randomly selected in a ferro-alloy plant and of 15 control subjects, platelet monoamine oxidase (MAO) and serum dopamine β-hydroxylase (DBH) activities were measured. A tendency towards lower MAO-B activity in the exposed workers as compared to control subjects (t = 1.95; P = 0.06) was found whereas DBH activity was similar. In the exposed group, a dose-effect relationship was noted between a manganese (Mn) cumulative exposure index (CEI) and DBH activity (R2 = 0.40, P < 0.05). Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Owing to the limited sample size, these findings should be confirmed by further epidemiological and experimental studies.

AB - In a preliminary study of 11 men randomly selected in a ferro-alloy plant and of 15 control subjects, platelet monoamine oxidase (MAO) and serum dopamine β-hydroxylase (DBH) activities were measured. A tendency towards lower MAO-B activity in the exposed workers as compared to control subjects (t = 1.95; P = 0.06) was found whereas DBH activity was similar. In the exposed group, a dose-effect relationship was noted between a manganese (Mn) cumulative exposure index (CEI) and DBH activity (R2 = 0.40, P < 0.05). Since DBH is an expression of catecholamine release, the relative increase in such activity could be envisaged as a compensatory mechanism to a reduced turnover rate as reflected by MAO-B activity. Owing to the limited sample size, these findings should be confirmed by further epidemiological and experimental studies.

KW - Catecholamine metabolism

KW - Mn

KW - Peripheral markers

UR - https://www.scopus.com/pages/publications/0029003746

U2 - 10.1016/0378-4274(95)03314-9

DO - 10.1016/0378-4274(95)03314-9

M3 - Article

C2 - 7618158

AN - SCOPUS:0029003746

SN - 0378-4274

VL - 77

SP - 329

EP - 333

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1-3

ER -

Peripheral markers of catecholamine metabolism among workers occupationally exposed to manganese (Mn)

Abstract

Keywords

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