Abstract
Splenic T cells proliferate in response to the anti-I-Ab reactive T cell hybridoma T 1.203 in an H-2-restricted but MHC antigen-independent manner. We propose that this anti-idiotypic response is mediated by "Type 2 autoreactive" T cells that are induced in peripheral lymphoid tissues following interaction with the particular idiotype expressed by the anti-self-I-A T cells. Thus, we define this phenomenon as an idiotype-restricted MHC-related cell interaction. To study the ontogeny of this response, we examined the distribution of Type 2 autoreactive cells. Spleen and lymph node but not thymic C57BL/6 T cells vigorously proliferate to T1.203. Mature (PNA-) as well as immature (PNA+) thymic T cells respond poorly. The frequency of cells responding to T1.203 is far greater in the spleen than in the thymus. The responding T cells were of both Lyt 1+ and Lyt 2+ T phenotype. The results suggest that Type 2 autoreactive cells are induced in peripheral lymphoid tissues following interaction with anti-I-A autoreactive T cells which escape from the thymus or develop in the periphery.
Original language | English |
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Pages (from-to) | 177-187 |
Number of pages | 11 |
Journal | Cellular Immunology |
Volume | 117 |
Issue number | 1 |
DOIs | |
State | Published - Nov 1988 |
Externally published | Yes |