Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study

Lawrence S. Geyman, Reena A. Garg, Yanin Suwan, Vivek Trivedi, Brian D. Krawitz, Shelley Mo, Alexander Pinhas, Apichat Tantraworasin, Toco Y.P. Chui, Robert Ritch, Richard B. Rosen

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Aims To assess peripapillary perfused capillary density (PCD) in primary open-angle glaucoma (POAG) across stage of disease. Methods In this observational, cross-sectional study, 60 eyes with varying stages of POAG and 24 control eyes were imaged on a spectral domain optical coherence tomography angiography system (AngioVue, Optovue, Fremont, California, USA) generating images centred on the optic nerve head. Major blood vessels were removed using custom automated software. PCD was calculated as a percentage as the ratio of pixels associated with perfused capillaries to the total number of pixels in the corresponding region-of-interest (ROI). Analysis of covariance was used to compare PCD among the subject groups and control for possible covariates. Area under the receiver operating characteristic curve (AROC) and sensitivity at 95% specificity were calculated to assess the capability of PCD to distinguish mild glaucoma from control. The Pearson's product-moment correlation coefficient was used to assess correlations between PCD and circumpapillary retinal nerve fibre layer thickness (cpRNFLT) and visual field mean deviation (MD). Results PCD demonstrated a progressive stepwise decrease from control eyes throughout worsening POAG stage at all ROIs. PCD demonstrated AROC and sensitivity values comparable to cpRNFLT and visual field parameters and exhibited significant correlations with cpRNFLT and MD at all corresponding ROIs. Conclusions PCD displayed significant correlations with morphological and functional indices and exhibited diagnostic capabilities comparable to currently employed clinical variables. Our preliminary results suggest that PCD analysis may prove to be a useful tool in monitoring POAG across stage and identifying early POAG.

Original languageEnglish
Pages (from-to)1261-1268
Number of pages8
JournalBritish Journal of Ophthalmology
Issue number9
StatePublished - Sep 2017
Externally publishedYes


  • Glaucoma
  • Imaging
  • Optic Nerve


Dive into the research topics of 'Peripapillary perfused capillary density in primary open - Angle glaucoma across disease stage: An optical coherence tomography angiography study'. Together they form a unique fingerprint.

Cite this