Periocular intralymphatic histiocytosis or localized Melkersson-Rosenthal syndrome?

Patrick O. Emanuel, Isabelle Lewis, Brent Gaskin, Paul Rosser, Neville Angelo

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We describe three cases of periocular edema with histopathologic features of intralymphatic histiocytosis without extravascular granulomas. All were elderly males with no other significant medical problems. Previous reports of periocular Melkersson-Rosenthal syndrome are identical clinically, and some reports show illustrations of intralymphatic histiocytosis histopathologically, in addition to other features typical of the syndrome. Given the lack of associated diseases or other features of the Melkersson-Rosenthal triad, some of these cases may be better defined as periocular intralymphatic histiocytosis.

Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalJournal of Cutaneous Pathology
Issue number4
StatePublished - 1 Apr 2015
Externally publishedYes


  • Melkersson-Rosenthal syndrome
  • histiocytes
  • intravascular
  • lymphatic
  • periocular


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