TY - JOUR
T1 - Perinatal exposure to fluoxetine via placenta and lactation inhibits the testicular development in male rat offspring
AU - De Oliveira, Waldo Monteiro
AU - De Sá, Iana Raphaela
AU - De Torres, Sandra Maria
AU - De Morais, Rosana Nogueira
AU - Andrade, Anderson Martino
AU - Maia, Frederico Celso Lyra
AU - Tenorio, Bruno Mendes
AU - Da Silva Junior, Valdemiro Amaro
PY - 2013/10
Y1 - 2013/10
N2 - Due to the widespread use of fluoxetine to treat depression, including pregnant and nursing women, the present study aimed to investigate the effects of in utero and lactational exposure to fluoxetine in rat offspring at post natal day 22. Wistar rat dams were orally treated with fluoxetine (5, 10, and 20mg/kg) from day 13 gestation to day 21 lactation. Exposure to 10 and 20mg/kg fluoxetine reduced the body and testis weights. The volume of the seminiferous tubules and epithelium were also reduced following 20mg/kg fluoxetine exposure. The length of the seminiferous tubules and the population of Sertoli cells changed in offspring exposed to fluoxetine. The amount of seminiferous tubules lacking tubular lumen was higher in rats exposed to 20mg/kg fluoxetine. Plasma testosterone showed no significant change. In conclusion, fluoxetine exposure via the placenta and lactation may inhibit and delay testicular development, adversely affecting several testicular parameters important for the establishment of sperm production in adulthood.
AB - Due to the widespread use of fluoxetine to treat depression, including pregnant and nursing women, the present study aimed to investigate the effects of in utero and lactational exposure to fluoxetine in rat offspring at post natal day 22. Wistar rat dams were orally treated with fluoxetine (5, 10, and 20mg/kg) from day 13 gestation to day 21 lactation. Exposure to 10 and 20mg/kg fluoxetine reduced the body and testis weights. The volume of the seminiferous tubules and epithelium were also reduced following 20mg/kg fluoxetine exposure. The length of the seminiferous tubules and the population of Sertoli cells changed in offspring exposed to fluoxetine. The amount of seminiferous tubules lacking tubular lumen was higher in rats exposed to 20mg/kg fluoxetine. Plasma testosterone showed no significant change. In conclusion, fluoxetine exposure via the placenta and lactation may inhibit and delay testicular development, adversely affecting several testicular parameters important for the establishment of sperm production in adulthood.
KW - Fluoxetine
KW - Leydig cell
KW - Serotonin
KW - Sertoli cell
KW - Testis
UR - https://www.scopus.com/pages/publications/84884667200
U2 - 10.3109/19396368.2013.796021
DO - 10.3109/19396368.2013.796021
M3 - Article
C2 - 23651434
AN - SCOPUS:84884667200
SN - 1939-6368
VL - 59
SP - 244
EP - 250
JO - Systems Biology in Reproductive Medicine
JF - Systems Biology in Reproductive Medicine
IS - 5
ER -