TY - JOUR
T1 - Perinatal and familial risk factors for irritable bowel syndrome in a Swedish national cohort
AU - Waehrens, Rasmus
AU - Li, Xinjun
AU - Sundquist, Jan
AU - Sundquist, Kristina
AU - Zöller, Bengt
N1 - Publisher Copyright:
© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/5/4
Y1 - 2018/5/4
N2 - Objective: Studies of the importance of perinatal factors for the development of irritable bowel syndrome (IBS) are sparse. We conducted a large national cohort study to examine perinatal and familial risk factors for IBS. Material and methods: A national cohort of 1,963,685 persons who were born in Sweden in 1973–1992 (identified from the Swedish Birth Registry) were followed up for adult (18 years and older) IBS incidence in the Swedish Patient Register through 2010 (maximum age 38 years). There were 24,633 IBS cases in 46,784,296 person-years of follow-up. Results: After adjusting for potential confounders, significant risk factors for IBS included caesarean (HR = 1.10, 95% confidence interval [CI] 1.05–1.11, p <.001), low birth weight (<2500g) (HR = 1.11, 95%CI 1.01–1.22, p =.02), being second in birth order (HR = 1.04, 95%CI 1.01–1.08, p =.01), foetal growth ≥1 SD (HR = 1.06, 95%CI 1.00–1.11, p =.05), young maternal age (<20 years) (HR= 1.09, 95%CI 1.02–1.17, p =.02), maternal marital status (divorced/widowed) (HR = 1.12, 95%CI 1.08–1.17, p <.001), maternal education of 10–11 years (HR = 1.04, 95%CI 1.01–1.08, p =.01), maternal education of 12–14 years (HR = 1.06, 95%CI 1.01–1.11, p =.03), parental history of IBS (HR = 1.54, 95%CI 1.42–1.66, p <.001), parental history of anxiety (HR = 1.21, 95%CI 1.17–1.26, p <.001) and parental history of depression (HR = 1.09, 95%CI 1.02–1.17, p =.02). Protective factors were male sex (HR = 0.36, 95%CI 0.35–0.37, p <.001) and old maternal at delivery (≥35 years) (HR = 0.95, 95%CI 0.90–1.00, p =.03). Conclusions: In this large cohort study, several perinatal and familial factors were associated with an increased risk of IBS independently, suggesting that perinatal and familial factors may play an important long-term role in the aetiology of IBS.
AB - Objective: Studies of the importance of perinatal factors for the development of irritable bowel syndrome (IBS) are sparse. We conducted a large national cohort study to examine perinatal and familial risk factors for IBS. Material and methods: A national cohort of 1,963,685 persons who were born in Sweden in 1973–1992 (identified from the Swedish Birth Registry) were followed up for adult (18 years and older) IBS incidence in the Swedish Patient Register through 2010 (maximum age 38 years). There were 24,633 IBS cases in 46,784,296 person-years of follow-up. Results: After adjusting for potential confounders, significant risk factors for IBS included caesarean (HR = 1.10, 95% confidence interval [CI] 1.05–1.11, p <.001), low birth weight (<2500g) (HR = 1.11, 95%CI 1.01–1.22, p =.02), being second in birth order (HR = 1.04, 95%CI 1.01–1.08, p =.01), foetal growth ≥1 SD (HR = 1.06, 95%CI 1.00–1.11, p =.05), young maternal age (<20 years) (HR= 1.09, 95%CI 1.02–1.17, p =.02), maternal marital status (divorced/widowed) (HR = 1.12, 95%CI 1.08–1.17, p <.001), maternal education of 10–11 years (HR = 1.04, 95%CI 1.01–1.08, p =.01), maternal education of 12–14 years (HR = 1.06, 95%CI 1.01–1.11, p =.03), parental history of IBS (HR = 1.54, 95%CI 1.42–1.66, p <.001), parental history of anxiety (HR = 1.21, 95%CI 1.17–1.26, p <.001) and parental history of depression (HR = 1.09, 95%CI 1.02–1.17, p =.02). Protective factors were male sex (HR = 0.36, 95%CI 0.35–0.37, p <.001) and old maternal at delivery (≥35 years) (HR = 0.95, 95%CI 0.90–1.00, p =.03). Conclusions: In this large cohort study, several perinatal and familial factors were associated with an increased risk of IBS independently, suggesting that perinatal and familial factors may play an important long-term role in the aetiology of IBS.
KW - Irritable bowel syndrome
KW - cohort studies
KW - epidemiology
KW - peripartum period
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=85033690903&partnerID=8YFLogxK
U2 - 10.1080/00365521.2017.1398345
DO - 10.1080/00365521.2017.1398345
M3 - Article
C2 - 29124972
AN - SCOPUS:85033690903
SN - 0036-5521
VL - 53
SP - 559
EP - 566
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
IS - 5
ER -