Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer

Carolina Mangana; Barbara B. Maier

doi:10.1016/j.ccell.2024.06.016

Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer

Carolina Mangana, Barbara B. Maier

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.

Original language	English
Pages (from-to)	1329-1331
Number of pages	3
Journal	Cancer Cell
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.ccell.2024.06.016
State	Published - 12 Aug 2024
Externally published	Yes

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10.1016/j.ccell.2024.06.016

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title = "Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer",

abstract = "Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.",

author = "Carolina Mangana and Maier, {Barbara B.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = aug,

day = "12",

doi = "10.1016/j.ccell.2024.06.016",

language = "English",

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journal = "Cancer Cell",

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T1 - Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer

AU - Mangana, Carolina

AU - Maier, Barbara B.

PY - 2024/8/12

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N2 - Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.

AB - Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.

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U2 - 10.1016/j.ccell.2024.06.016

DO - 10.1016/j.ccell.2024.06.016

M3 - Comment/debate

C2 - 39029467

AN - SCOPUS:85200551495

SN - 1535-6108

VL - 42

SP - 1329

EP - 1331

JO - Cancer Cell

JF - Cancer Cell

IS - 8

ER -

Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer

Abstract

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