Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy

Johan L. Dikken; Daniel G. Coit; Raymond E. Baser; Mithat Gönen; Karyn A. Goodman; Murray F. Brennan; Edwin P.M. Jansen; Henk Boot; Cornelis J.H. Van De Velde; Annemieke Cats; Marcel Verheij

doi:10.1016/j.ijrobp.2013.11.213

Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy

Johan L. Dikken, Daniel G. Coit, Raymond E. Baser, Mithat Gönen, Karyn A. Goodman, Murray F. Brennan, Edwin P.M. Jansen, Henk Boot, Cornelis J.H. Van De Velde, Annemieke Cats, Marcel Verheij

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.

Original language	English
Pages (from-to)	624-629
Number of pages	6
Journal	International Journal of Radiation Oncology Biology Physics
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.ijrobp.2013.11.213
State	Published - 1 Mar 2014
Externally published	Yes

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10.1016/j.ijrobp.2013.11.213

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Dikken, J. L., Coit, D. G., Baser, R. E., Gönen, M., Goodman, K. A., Brennan, M. F., Jansen, E. P. M., Boot, H., Van De Velde, C. J. H., Cats, A., & Verheij, M. (2014). Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy. International Journal of Radiation Oncology Biology Physics, 88(3), 624-629. https://doi.org/10.1016/j.ijrobp.2013.11.213

@article{61bed088ff424453a4829c2b10b2b22b,

title = "Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy",

abstract = "Purpose The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.",

author = "Dikken, {Johan L.} and Coit, {Daniel G.} and Baser, {Raymond E.} and Mithat G{\"o}nen and Goodman, {Karyn A.} and Brennan, {Murray F.} and Jansen, {Edwin P.M.} and Henk Boot and {Van De Velde}, {Cornelis J.H.} and Annemieke Cats and Marcel Verheij",

note = "Funding Information: The authors thank Marianne Beninati for her contribution to data management. This research was funded in part by the Prof. Michael van Vloten foundation , the Dutch Cancer Society (KWF Kankerbestrijding) , the Dutch Digestive Foundation , and the Jo Keur Foundation . The funding sources had no involvement in study design, data collection, data analysis, manuscript preparation, or publication decisions.",

year = "2014",

month = mar,

day = "1",

doi = "10.1016/j.ijrobp.2013.11.213",

language = "English",

volume = "88",

pages = "624--629",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

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number = "3",

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Dikken, JL, Coit, DG, Baser, RE, Gönen, M, Goodman, KA, Brennan, MF, Jansen, EPM, Boot, H, Van De Velde, CJH, Cats, A & Verheij, M 2014, 'Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy', International Journal of Radiation Oncology Biology Physics, vol. 88, no. 3, pp. 624-629. https://doi.org/10.1016/j.ijrobp.2013.11.213

Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy. / Dikken, Johan L.; Coit, Daniel G.; Baser, Raymond E. et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 88, No. 3, 01.03.2014, p. 624-629.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy

AU - Dikken, Johan L.

AU - Coit, Daniel G.

AU - Baser, Raymond E.

AU - Gönen, Mithat

AU - Goodman, Karyn A.

AU - Brennan, Murray F.

AU - Jansen, Edwin P.M.

AU - Boot, Henk

AU - Van De Velde, Cornelis J.H.

AU - Cats, Annemieke

AU - Verheij, Marcel

N1 - Funding Information: The authors thank Marianne Beninati for her contribution to data management. This research was funded in part by the Prof. Michael van Vloten foundation , the Dutch Cancer Society (KWF Kankerbestrijding) , the Dutch Digestive Foundation , and the Jo Keur Foundation . The funding sources had no involvement in study design, data collection, data analysis, manuscript preparation, or publication decisions.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Purpose The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.

AB - Purpose The internationally validated Memorial Sloan-Kettering Cancer Center (MSKCC) gastric carcinoma nomogram was based on patients who underwent curative (R0) gastrectomy, without any other therapy. The purpose of the current study was to assess the performance of this gastric cancer nomogram in patients who received chemoradiation therapy after an R0 resection for gastric cancer. Methods and Materials In a combined dataset of 76 patients from the Netherlands Cancer Institute (NKI), and 63 patients from MSKCC, who received postoperative chemoradiation therapy (CRT) after an R0 gastrectomy, the nomogram was validated by means of the concordance index (CI) and a calibration plot. Results The concordance index for the nomogram was 0.64, which was lower than the CI of the nomogram for patients who received no adjuvant therapy (0.80). In the calibration plot, observed survival was approximately 20% higher than the nomogram-predicted survival for patients receiving postoperative CRT. Conclusions The MSKCC gastric carcinoma nomogram significantly underpredicted survival for patients in the current study, suggesting an impact of postoperative CRT on survival in patients who underwent an R0 resection for gastric cancer, which has been demonstrated by randomized controlled trials. This analysis stresses the need for updating nomograms with the incorporation of multimodal strategies.

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U2 - 10.1016/j.ijrobp.2013.11.213

DO - 10.1016/j.ijrobp.2013.11.213

M3 - Article

C2 - 24411620

AN - SCOPUS:84893831764

SN - 0360-3016

VL - 88

SP - 624

EP - 629

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 3

ER -

Performance of a nomogram predicting disease-specific survival after an R0 resection for gastric cancer in patients receiving postoperative chemoradiation therapy

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