Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary

Jeffrey A. Haspel; Ron Anafi; Marishka K. Brown; Nicolas Cermakian; Christopher Depner; Paula Desplats; Andrew E. Gelman; Monika Haack; Sanja Jelic; Brian S. Kim; Aaron D. Laposky; Yvonne C. Lee; Emmanuel Mongodin; Aric A. Prather; Brian Prendergast; Colin Reardon; Albert C. Shaw; Shaon Sengupta; Éva Szentirmai; Mahesh Thakkar; Wendy E. Walker; Laura A. Solt

doi:10.1172/jci.insight.131487

Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary

Jeffrey A. Haspel, Ron Anafi, Marishka K. Brown, Nicolas Cermakian, Christopher Depner, Paula Desplats, Andrew E. Gelman, Monika Haack, Sanja Jelic, Brian S. Kim, Aaron D. Laposky, Yvonne C. Lee, Emmanuel Mongodin, Aric A. Prather, Brian Prendergast, Colin Reardon, Albert C. Shaw, Shaon Sengupta, Éva Szentirmai, Mahesh ThakkarWendy E. Walker, Laura A. Solt

Research output: Contribution to journal › Review article › peer-review

151 Scopus citations

Abstract

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

Original language	English
Article number	e131487
Journal	JCI insight
Volume	5
Issue number	1
DOIs	https://doi.org/10.1172/jci.insight.131487
State	Published - 2020
Externally published	Yes

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Haspel, J. A., Anafi, R., Brown, M. K., Cermakian, N., Depner, C., Desplats, P., Gelman, A. E., Haack, M., Jelic, S., Kim, B. S., Laposky, A. D., Lee, Y. C., Mongodin, E., Prather, A. A., Prendergast, B., Reardon, C., Shaw, A. C., Sengupta, S., Szentirmai, É., ... Solt, L. A. (2020). Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary. JCI insight, 5(1), Article e131487. https://doi.org/10.1172/jci.insight.131487

@article{c90a71affb0140299b3c63483c25a523,

title = "Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary",

abstract = "Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.",

author = "Haspel, {Jeffrey A.} and Ron Anafi and Brown, {Marishka K.} and Nicolas Cermakian and Christopher Depner and Paula Desplats and Gelman, {Andrew E.} and Monika Haack and Sanja Jelic and Kim, {Brian S.} and Laposky, {Aaron D.} and Lee, {Yvonne C.} and Emmanuel Mongodin and Prather, {Aric A.} and Brian Prendergast and Colin Reardon and Shaw, {Albert C.} and Shaon Sengupta and {\'E}va Szentirmai and Mahesh Thakkar and Walker, {Wendy E.} and Solt, {Laura A.}",

note = "Publisher Copyright: {\textcopyright} 2020, American Society for Clinical Investigation.",

year = "2020",

doi = "10.1172/jci.insight.131487",

language = "English",

volume = "5",

journal = "JCI insight",

issn = "2379-3708",

publisher = "American Society for Clinical Investigation",

number = "1",

}

Haspel, JA, Anafi, R, Brown, MK, Cermakian, N, Depner, C, Desplats, P, Gelman, AE, Haack, M, Jelic, S, Kim, BS, Laposky, AD, Lee, YC, Mongodin, E, Prather, AA, Prendergast, B, Reardon, C, Shaw, AC, Sengupta, S, Szentirmai, É, Thakkar, M, Walker, WE & Solt, LA 2020, 'Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary', JCI insight, vol. 5, no. 1, e131487. https://doi.org/10.1172/jci.insight.131487

TY - JOUR

T1 - Perfect timing

T2 - Circadian rhythms, sleep, and immunity — An NIH workshop summary

AU - Haspel, Jeffrey A.

AU - Anafi, Ron

AU - Brown, Marishka K.

AU - Cermakian, Nicolas

AU - Depner, Christopher

AU - Desplats, Paula

AU - Gelman, Andrew E.

AU - Haack, Monika

AU - Jelic, Sanja

AU - Kim, Brian S.

AU - Laposky, Aaron D.

AU - Lee, Yvonne C.

AU - Mongodin, Emmanuel

AU - Prather, Aric A.

AU - Prendergast, Brian

AU - Reardon, Colin

AU - Shaw, Albert C.

AU - Sengupta, Shaon

AU - Szentirmai, Éva

AU - Thakkar, Mahesh

AU - Walker, Wendy E.

AU - Solt, Laura A.

PY - 2020

Y1 - 2020

N2 - Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

AB - Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses — ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation —are mediated in a time of day–dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, and the Immune Response,” to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

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AN - SCOPUS:85079551046

SN - 2379-3708

VL - 5

JO - JCI insight

JF - JCI insight

IS - 1

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ER -

Perfect timing: Circadian rhythms, sleep, and immunity — An NIH workshop summary

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