TY - JOUR
T1 - Percutaneous LAAO and Pulsed-Field Isolation in a Canine Model
T2 - Feasibility and Safety Evaluation
AU - Yu, Fengyuan
AU - Dong, Xiaonan
AU - Sun, Yang
AU - Reddy, Vivek
AU - Sievert, Horst
AU - Tang, Min
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/8
Y1 - 2024/8
N2 - In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies.
AB - In this study, we investigated the feasibility, safety, and efficiency of using a novel device system to perform percutaneous left atrial appendage occlusion concomitant with left atrial appendage electrical isolation (LAAEI) via pulsed field ablation. In the acute phase, LAAEI was successful in 10 of 10 canines. At follow-up, full endothelialization was observed in 5 of 5 (100%) cases at 6 months. LAAEI was durable in 8 of 10 (80.00%) canines. Histologic examination in 4 of 6 LAAs with durable isolation showed transmural scars comprising fibrosis and fat. No pericardial effusion or phrenic paralysis was observed at follow-up. This preliminary study provides the scientific basis for first-in-human studies.
KW - atrial fibrillation
KW - left atrial appendage electrical isolation
KW - left atrial appendage occlusion
KW - lesion durability
KW - pulsed field ablation
UR - https://www.scopus.com/pages/publications/85200894034
U2 - 10.1016/j.jacbts.2024.05.008
DO - 10.1016/j.jacbts.2024.05.008
M3 - Article
AN - SCOPUS:85200894034
SN - 2452-302X
VL - 9
SP - 971
EP - 981
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 8
ER -