@article{9d8d2132d6a4440e9b6411977b4837e4,
title = "Percutaneous absorption of steroids.",
author = "Scheuplein, \{R. J.\} and Blank, \{I. H.\} and Brauner, \{G. J.\} and MacFarlane, \{D. J.\}",
note = "Funding Information: skin's principal rate limiting barrier. 2. Diffusion constants through hydrated stratum corneum for many low molecular weight or- ganic compounds (G1—C5) are approximately the same, i.e., D = 10° cm2 sec'. a. The diffusion constant for a molecule decreases as more polar groups, particu- larly hydroxyl groups, are introduced. b. The activation energy for the diffusion of polar molecules is higher than for their less polar analogues and increases markedly as additional polar groups are added. 3. Within a given molecular series (of constant or nearly constant diffusivity D) the ob- served steady state flux J and permeability constant ice are directly proportional to the relative solubility of the substance in the skin as expressed by the membrane: solvent partition coefficient, Km , i.e., \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ This investigation was supported in part by United States Pubhc Health Service Research Grant GM 13997 from the National Institute of General Medical Sciences and in part by Lederle Laboratories, Pearl River, New York.",
year = "1969",
month = jan,
doi = "10.1038/jid.1969.9",
language = "English",
volume = "52",
pages = "63--70",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Elsevier B.V.",
number = "1",
}