Perampanel, an AMPA antagonist, found to have no benefit in reducing "off" time in Parkinson's disease

Andrew Lees, Stanley Fahn, Karla M. Eggert, Joseph Jankovic, Anthony Lang, Federico Micheli, M. Maral Mouradian, Wolfgang H. Oertel, C. Warren Olanow, Werner Poewe, Olivier Rascol, Eduardo Tolosa, David Squillacote, Dinesh Kumar

Research output: Contribution to journalComment/debate

65 Scopus citations


Background: Perampanel is a selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist. Two multicenter randomized, double-blind, placebo-controlled, parallel-group phase III studies assessed the efficacy and safety of adjunctive perampanel in patients with Parkinson's disease and motor fluctuations. Methods: In both phase III studies (301 and 302), levodopa-treated patients were randomized and treated with once-daily oral placebo (n = 504), perampanel 2 mg (n = 509), or perampanel 4 mg (n = 501). The primary end point was change in daily "off" time from baseline. The treatment period was 30 weeks in study 301 and 20 weeks in study 302. Results: For any efficacy end point, perampanel 2 or 4 mg was not superior to placebo. Perampanel was well tolerated up to 4 mg/day. Conclusions: Perampanel failed to significantly improve motor symptoms versus placebo. There was also no effect on the duration or disability of levodopa-induced dyskinesia.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalMovement Disorders
Issue number2
StatePublished - Feb 2012


  • AMPA receptor antagonist
  • Efficacy
  • Motor fluctuations
  • Parkinson's disease
  • Perampanel
  • Safety


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