Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―

Takayuki Warisawa; Christopher M. Cook; Henry Seligman; James P. Howard; Yousif Ahmad; Christopher Rajkumar; Shunichi Doi; Masafumi Nakayama; Toru Tanigaki; Hiroyuki Omori; Akihiro Nakajima; Futoshi Yamanaka; Sonoka Goto; Yohei Yakuta; Kenichi Karube; Teruyoshi Uetani; Yuetsu Kikuta; Yasutsugu Shiono; Yoshiaki Kawase; Hidetaka Nishina; Sunao Nakamura; Javier Escaned; Yoshihiro J. Akashi; Hitoshi Matsuo; Justin E. Davies

doi:10.1253/circj.CJ-19-0785

Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―

Takayuki Warisawa
, Christopher M. Cook
, Henry Seligman
, James P. Howard
, Yousif Ahmad
, Christopher Rajkumar
, Shunichi Doi
, Masafumi Nakayama
, Toru Tanigaki
, Hiroyuki Omori
, Akihiro Nakajima
, Futoshi Yamanaka
, Sonoka Goto
, Yohei Yakuta
, Kenichi Karube
, Teruyoshi Uetani
, Yuetsu Kikuta
, Yasutsugu Shiono
, Yoshiaki Kawase
, Hidetaka Nishina

Sunao Nakamura, Javier Escaned, Yoshihiro J. Akashi, Hitoshi Matsuo, Justin E. Davies

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified. Methods and Results: Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR−/ iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR− (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17). Conclusions: The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.

Original language	English
Pages (from-to)	1034-1038
Number of pages	5
Journal	Circulation Journal
Volume	84
Issue number	6
DOIs	https://doi.org/10.1253/circj.CJ-19-0785
State	Published - 2020
Externally published	Yes

Keywords

Diffuse disease
Fractional flow reserve
Instantaneous wave-free ratio

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10.1253/circj.CJ-19-0785

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Warisawa, T., Cook, C. M., Seligman, H., Howard, J. P., Ahmad, Y., Rajkumar, C., Doi, S., Nakayama, M., Tanigaki, T., Omori, H., Nakajima, A., Yamanaka, F., Goto, S., Yakuta, Y., Karube, K., Uetani, T., Kikuta, Y., Shiono, Y., Kawase, Y., ... Davies, J. E. (2020). Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―. Circulation Journal, 84(6), 1034-1038. https://doi.org/10.1253/circj.CJ-19-0785

@article{92457e3da8894fc7a8c790a31f43c7c7,

title = "Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―",

abstract = "Background: The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified. Methods and Results: Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8\%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR−/ iFR+ (83.3\% [40/48]), while physiologically focal disease was associated with FFR+/iFR− (57.4\% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17). Conclusions: The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.",

keywords = "Diffuse disease, Fractional flow reserve, Instantaneous wave-free ratio",

author = "Takayuki Warisawa and Cook, \{Christopher M.\} and Henry Seligman and Howard, \{James P.\} and Yousif Ahmad and Christopher Rajkumar and Shunichi Doi and Masafumi Nakayama and Toru Tanigaki and Hiroyuki Omori and Akihiro Nakajima and Futoshi Yamanaka and Sonoka Goto and Yohei Yakuta and Kenichi Karube and Teruyoshi Uetani and Yuetsu Kikuta and Yasutsugu Shiono and Yoshiaki Kawase and Hidetaka Nishina and Sunao Nakamura and Javier Escaned and Akashi, \{Yoshihiro J.\} and Hitoshi Matsuo and Davies, \{Justin E.\}",

year = "2020",

doi = "10.1253/circj.CJ-19-0785",

language = "English",

volume = "84",

pages = "1034--1038",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "6",

}

Warisawa, T, Cook, CM, Seligman, H, Howard, JP, Ahmad, Y, Rajkumar, C, Doi, S, Nakayama, M, Tanigaki, T, Omori, H, Nakajima, A, Yamanaka, F, Goto, S, Yakuta, Y, Karube, K, Uetani, T, Kikuta, Y, Shiono, Y, Kawase, Y, Nishina, H, Nakamura, S, Escaned, J, Akashi, YJ, Matsuo, H & Davies, JE 2020, 'Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―', Circulation Journal, vol. 84, no. 6, pp. 1034-1038. https://doi.org/10.1253/circj.CJ-19-0785

TY - JOUR

T1 - Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―

AU - Warisawa, Takayuki

AU - Cook, Christopher M.

AU - Seligman, Henry

AU - Howard, James P.

AU - Ahmad, Yousif

AU - Rajkumar, Christopher

AU - Doi, Shunichi

AU - Nakayama, Masafumi

AU - Tanigaki, Toru

AU - Omori, Hiroyuki

AU - Nakajima, Akihiro

AU - Yamanaka, Futoshi

AU - Goto, Sonoka

AU - Yakuta, Yohei

AU - Karube, Kenichi

AU - Uetani, Teruyoshi

AU - Kikuta, Yuetsu

AU - Shiono, Yasutsugu

AU - Kawase, Yoshiaki

AU - Nishina, Hidetaka

AU - Nakamura, Sunao

AU - Escaned, Javier

AU - Akashi, Yoshihiro J.

AU - Matsuo, Hitoshi

AU - Davies, Justin E.

PY - 2020

Y1 - 2020

N2 - Background: The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified. Methods and Results: Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR−/ iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR− (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17). Conclusions: The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.

AB - Background: The per-vessel level impact of physiological pattern of disease on the discordance between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) has not been clarified. Methods and Results: Using the AJIP registry, vessels with FFR/iFR discordance (133/671 [19.8%]) were analyzed. In the left anterior descending artery (LAD), physiologically diffuse disease, as assessed by pressure-wire pullback, was associated with FFR−/ iFR+ (83.3% [40/48]), while physiologically focal disease was associated with FFR+/iFR− (57.4% [31/54]), significantly (P<0.0001). These differences were not significant in non-LAD (P=0.17). Conclusions: The impact of physiological pattern of disease on FFR/iFR discordance is more pronounced in the LAD.

KW - Diffuse disease

KW - Fractional flow reserve

KW - Instantaneous wave-free ratio

UR - https://www.scopus.com/pages/publications/85085535000

U2 - 10.1253/circj.CJ-19-0785

DO - 10.1253/circj.CJ-19-0785

M3 - Article

C2 - 32321880

AN - SCOPUS:85085535000

SN - 1346-9843

VL - 84

SP - 1034

EP - 1038

JO - Circulation Journal

JF - Circulation Journal

IS - 6

ER -

Per-vessel level analysis of fractional flow reserve and instantaneous wave-free ratio discordance ― insights from the AJIP registry ―

Abstract

Keywords

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