TY - JOUR
T1 - Peptides as materials
AU - Pepe-Mooney, Brian J.
AU - Fairman, Robert
N1 - Funding Information:
We gratefully acknowledge grant support from NSF (CHE-0616615 and MCB-0516025 to RF), and institutional grants from the Arnold and Mabel Beckman Foundation and the HHMI Undergraduate Science Education Program, which support undergraduate research.
PY - 2009/8
Y1 - 2009/8
N2 - This review focuses on the creation of electronically active peptide-based biomaterials and how such materials may be deposited onto surfaces to create integrated bionanocircuits. We describe recent efforts to add electronically active groups, such as metal complexes and various porphyrin derivatives, onto peptide-based materials. Having created such materials, the next challenge in creating a nanocircuit is to deposit these materials robustly and precisely onto appropriate surfaces. Methods for the deposition of peptides onto a variety of inorganic and organic surfaces are explored. Advances in patterning at the nanoscale are also described, focusing largely on softer methods appropriate for peptides. There are challenges yet to be overcome in realizing such peptide-based nanocircuits; these are discussed in our concluding remarks.
AB - This review focuses on the creation of electronically active peptide-based biomaterials and how such materials may be deposited onto surfaces to create integrated bionanocircuits. We describe recent efforts to add electronically active groups, such as metal complexes and various porphyrin derivatives, onto peptide-based materials. Having created such materials, the next challenge in creating a nanocircuit is to deposit these materials robustly and precisely onto appropriate surfaces. Methods for the deposition of peptides onto a variety of inorganic and organic surfaces are explored. Advances in patterning at the nanoscale are also described, focusing largely on softer methods appropriate for peptides. There are challenges yet to be overcome in realizing such peptide-based nanocircuits; these are discussed in our concluding remarks.
UR - http://www.scopus.com/inward/record.url?scp=69249158648&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2009.07.001
DO - 10.1016/j.sbi.2009.07.001
M3 - Review article
C2 - 19643595
AN - SCOPUS:69249158648
SN - 0959-440X
VL - 19
SP - 483
EP - 494
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 4
ER -