Peptide-mediated interference with influenza A virus polymerase

Alexander Ghanem, Daniel Mayer, Geoffrey Chase, Werner Tegge, Ronald Frank, Georg Kochs, Adolfo García-Sastre, Martin Schwemmle

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interfere with polymerase complex assembly and inhibit viral replication. Specifically, we provide evidence that a 25-amino-acid peptide corresponding to the PA-binding domain of PB1 blocks the polymerase activity of influenza A virus and inhibits viral spread. Targeting polymerase subunit interactions therefore provides a novel strategy to develop antiviral compounds against influenza A virus or other viruses.

Original languageEnglish
Pages (from-to)7801-7804
Number of pages4
JournalJournal of Virology
Volume81
Issue number14
DOIs
StatePublished - Jul 2007

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