Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease

Valerie Pittet; Gerhard Rogler; Pierre Michetti; Nicolas Fournier; John Paul Vader; Alain Schoepfer; Christian Mottet; Bernard Burnand; Florian Froehlich; Peter Bauerfeind; Christoph Beglinger; Stefan Begré; Dominique Belli; José Bengoa; Luc Biedermann; Janek Binek; Jan Borovicka; Christian Braegger; Patrick Bühr; Emanuel Burri; Rafael Camara; Dominique Criblez; Philippe De Saussure; Lukas Degen; Mohamed Ali Delhavi; Joakim Delarive; Christopher Dörig; Gian Dorta; Tobias Ehmann; Ali El Wafa; Christian Felley; Markus Fliegner; Alain Frei; Pascal Frei; Remus Frei; Michael Fried; Michael Friedt; Heiko Frühauf; Raoul Furlano; Suzanne Gallot-Lavallée; Martin Geyer; Marc Girardin; Sébastien Godat; Jean Jacques Gonvers; Ignaz Good; Oliver Götze; Beat Gysi; Antoine Hadengue; Marcel Halama; Serge Hediger; Pius Heer; Beat Helbling; Mona Hellstern; Peter Hengstler; Denise Herzog; Cyrill Hess; Klaas Heyland; Thomas Hinterleitner; Philippe Hiroz; Claudia Hirschi; Petr Hruz; Patrick Janiak; Christian Jost; Pascal Juillerat; Vera Kessler Brondolo; Christoph Knoblauch; Claudia Krieger; Gerd A. Kullak-Ublick; Markus Landolt; En Ling Leung-Ki; Philippe Maerten; Michel Maillard; Christine Manser; Michael Manz; Urs Marbet; Igor Marsteller; Rémy Meier; Christa Meyenberger; David Mondada; Darius Moradpour; Patrick Mosler; Christoph Müller; Pascal Müller; Beat Müllhaupt; Andreas Nagy; Cristina Nichita; Thierry Nicolet; Hansjürg Nüesch; Andreas Nydegger; Isabelle Pache; Franziska Piccoli; Julia Pilz; Bruno Raffa; Ronald Rentsch; Jean Pierre Rey; Daniela Rogler; Markus Sagmeister; Bernhard Sauter; Mikael Sawatzki; Gerold Schacher; Michael Scharl; Nora Schaub; Martin Schellin; Susanne Schibli; Hugo Schlauri; Jean François Schnegg; Franck Seibold; Mariam Seirafi; David Semela; Marc Sidler; Johannes Spalinger; Holger Spangenberger; Philippe Stadler; Peter Staub; Michael Steuerwald; Alex Straumann; Michael Sulz; Michela Tempia-Caliera; Joël Thorens; Radu Tutuian; Stephan Vavricka; Dominique Velin; Francesco Viani; Roland Von Känel; Alain Vonlaufen; Dominique Vouillamoz; Gert Wachter; Jürg Wermuth; Paul Wiesel; Samuel Zamora; Jonas Zeitz

doi:10.1159/000350954

Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease

Valerie Pittet, Gerhard Rogler, Pierre Michetti, Nicolas Fournier, John Paul Vader, Alain Schoepfer, Christian Mottet, Bernard Burnand, Florian Froehlich, Peter Bauerfeind, Christoph Beglinger, Stefan Begré, Dominique Belli, José Bengoa, Luc Biedermann, Janek Binek, Jan Borovicka, Christian Braegger, Patrick Bühr, Emanuel BurriRafael Camara, Dominique Criblez, Philippe De Saussure, Lukas Degen, Mohamed Ali Delhavi, Joakim Delarive, Christopher Dörig, Gian Dorta, Tobias Ehmann, Ali El Wafa, Christian Felley, Markus Fliegner, Alain Frei, Pascal Frei, Remus Frei, Michael Fried, Michael Friedt, Heiko Frühauf, Raoul Furlano, Suzanne Gallot-Lavallée, Martin Geyer, Marc Girardin, Sébastien Godat, Jean Jacques Gonvers, Ignaz Good, Oliver Götze, Beat Gysi, Antoine Hadengue, Marcel Halama, Serge Hediger, Pius Heer, Beat Helbling, Mona Hellstern, Peter Hengstler, Denise Herzog, Cyrill Hess, Klaas Heyland, Thomas Hinterleitner, Philippe Hiroz, Claudia Hirschi, Petr Hruz, Patrick Janiak, Christian Jost, Pascal Juillerat, Vera Kessler Brondolo, Christoph Knoblauch, Claudia Krieger, Gerd A. Kullak-Ublick, Markus Landolt, En Ling Leung-Ki, Philippe Maerten, Michel Maillard, Christine Manser, Michael Manz, Urs Marbet, Igor Marsteller, Rémy Meier, Christa Meyenberger, David Mondada, Darius Moradpour, Patrick Mosler, Christoph Müller, Pascal Müller, Beat Müllhaupt, Andreas Nagy, Cristina Nichita, Thierry Nicolet, Hansjürg Nüesch, Andreas Nydegger, Isabelle Pache, Franziska Piccoli, Julia Pilz, Bruno Raffa, Ronald Rentsch, Jean Pierre Rey, Daniela Rogler, Markus Sagmeister, Bernhard Sauter, Mikael Sawatzki, Gerold Schacher, Michael Scharl, Nora Schaub, Martin Schellin, Susanne Schibli, Hugo Schlauri, Jean François Schnegg, Franck Seibold, Mariam Seirafi, David Semela, Marc Sidler, Johannes Spalinger, Holger Spangenberger, Philippe Stadler, Peter Staub, Michael Steuerwald, Alex Straumann, Michael Sulz, Michela Tempia-Caliera, Joël Thorens, Radu Tutuian, Stephan Vavricka, Dominique Velin, Francesco Viani, Roland Von Känel, Alain Vonlaufen, Dominique Vouillamoz, Gert Wachter, Jürg Wermuth, Paul Wiesel, Samuel Zamora, Jonas Zeitz

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. Methods: Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. Results: Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). Conclusion: The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.

Original language	English
Pages (from-to)	212-221
Number of pages	10
Journal	Digestion
Volume	87
Issue number	3
DOIs	https://doi.org/10.1159/000350954
State	Published - Jun 2013

Keywords

Crohn's disease
Epidemiology
Surgery for IBD

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10.1159/000350954

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Pittet, V., Rogler, G., Michetti, P., Fournier, N., Vader, J. P., Schoepfer, A., Mottet, C., Burnand, B., Froehlich, F., Bauerfeind, P., Beglinger, C., Begré, S., Belli, D., Bengoa, J., Biedermann, L., Binek, J., Borovicka, J., Braegger, C., Bühr, P., ... Zeitz, J. (2013). Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease. Digestion, 87(3), 212-221. https://doi.org/10.1159/000350954

@article{89661a4fb6f040c79248c6d613e49642,

title = "Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease",

abstract = "Background: About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. Methods: Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. Results: Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). Conclusion: The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.",

keywords = "Crohn's disease, Epidemiology, Surgery for IBD",

author = "Valerie Pittet and Gerhard Rogler and Pierre Michetti and Nicolas Fournier and Vader, {John Paul} and Alain Schoepfer and Christian Mottet and Bernard Burnand and Florian Froehlich and Peter Bauerfeind and Christoph Beglinger and Stefan Begr{\'e} and Dominique Belli and Jos{\'e} Bengoa and Luc Biedermann and Janek Binek and Jan Borovicka and Christian Braegger and Patrick B{\"u}hr and Emanuel Burri and Rafael Camara and Dominique Criblez and {De Saussure}, Philippe and Lukas Degen and Delhavi, {Mohamed Ali} and Joakim Delarive and Christopher D{\"o}rig and Gian Dorta and Tobias Ehmann and {El Wafa}, Ali and Christian Felley and Markus Fliegner and Alain Frei and Pascal Frei and Remus Frei and Michael Fried and Michael Friedt and Heiko Fr{\"u}hauf and Raoul Furlano and Suzanne Gallot-Lavall{\'e}e and Martin Geyer and Marc Girardin and S{\'e}bastien Godat and Gonvers, {Jean Jacques} and Ignaz Good and Oliver G{\"o}tze and Beat Gysi and Antoine Hadengue and Marcel Halama and Serge Hediger and Pius Heer and Beat Helbling and Mona Hellstern and Peter Hengstler and Denise Herzog and Cyrill Hess and Klaas Heyland and Thomas Hinterleitner and Philippe Hiroz and Claudia Hirschi and Petr Hruz and Patrick Janiak and Christian Jost and Pascal Juillerat and Brondolo, {Vera Kessler} and Christoph Knoblauch and Claudia Krieger and Kullak-Ublick, {Gerd A.} and Markus Landolt and Leung-Ki, {En Ling} and Philippe Maerten and Michel Maillard and Christine Manser and Michael Manz and Urs Marbet and Igor Marsteller and R{\'e}my Meier and Christa Meyenberger and David Mondada and Darius Moradpour and Patrick Mosler and Christoph M{\"u}ller and Pascal M{\"u}ller and Beat M{\"u}llhaupt and Andreas Nagy and Cristina Nichita and Thierry Nicolet and Hansj{\"u}rg N{\"u}esch and Andreas Nydegger and Isabelle Pache and Franziska Piccoli and Julia Pilz and Bruno Raffa and Ronald Rentsch and Rey, {Jean Pierre} and Daniela Rogler and Markus Sagmeister and Bernhard Sauter and Mikael Sawatzki and Gerold Schacher and Michael Scharl and Nora Schaub and Martin Schellin and Susanne Schibli and Hugo Schlauri and Schnegg, {Jean Fran{\c c}ois} and Franck Seibold and Mariam Seirafi and David Semela and Marc Sidler and Johannes Spalinger and Holger Spangenberger and Philippe Stadler and Peter Staub and Michael Steuerwald and Alex Straumann and Michael Sulz and Michela Tempia-Caliera and Jo{\"e}l Thorens and Radu Tutuian and Stephan Vavricka and Dominique Velin and Francesco Viani and {Von K{\"a}nel}, Roland and Alain Vonlaufen and Dominique Vouillamoz and Gert Wachter and J{\"u}rg Wermuth and Paul Wiesel and Samuel Zamora and Jonas Zeitz",

year = "2013",

month = jun,

doi = "10.1159/000350954",

language = "English",

volume = "87",

pages = "212--221",

journal = "Digestion",

issn = "0012-2823",

publisher = "S. Karger AG",

number = "3",

}

Pittet, V, Rogler, G, Michetti, P, Fournier, N, Vader, JP, Schoepfer, A, Mottet, C, Burnand, B, Froehlich, F, Bauerfeind, P, Beglinger, C, Begré, S, Belli, D, Bengoa, J, Biedermann, L, Binek, J, Borovicka, J, Braegger, C, Bühr, P, Burri, E, Camara, R, Criblez, D, De Saussure, P, Degen, L, Delhavi, MA, Delarive, J, Dörig, C, Dorta, G, Ehmann, T, El Wafa, A, Felley, C, Fliegner, M, Frei, A, Frei, P, Frei, R, Fried, M, Friedt, M, Frühauf, H, Furlano, R, Gallot-Lavallée, S, Geyer, M, Girardin, M, Godat, S, Gonvers, JJ, Good, I, Götze, O, Gysi, B, Hadengue, A, Halama, M, Hediger, S, Heer, P, Helbling, B, Hellstern, M, Hengstler, P, Herzog, D, Hess, C, Heyland, K, Hinterleitner, T, Hiroz, P, Hirschi, C, Hruz, P, Janiak, P, Jost, C, Juillerat, P, Brondolo, VK, Knoblauch, C, Krieger, C, Kullak-Ublick, GA, Landolt, M, Leung-Ki, EL, Maerten, P, Maillard, M, Manser, C, Manz, M, Marbet, U, Marsteller, I, Meier, R, Meyenberger, C, Mondada, D, Moradpour, D, Mosler, P, Müller, C, Müller, P, Müllhaupt, B, Nagy, A, Nichita, C, Nicolet, T, Nüesch, H, Nydegger, A, Pache, I, Piccoli, F, Pilz, J, Raffa, B, Rentsch, R, Rey, JP, Rogler, D, Sagmeister, M, Sauter, B, Sawatzki, M, Schacher, G, Scharl, M, Schaub, N, Schellin, M, Schibli, S, Schlauri, H, Schnegg, JF, Seibold, F, Seirafi, M, Semela, D, Sidler, M, Spalinger, J, Spangenberger, H, Stadler, P, Staub, P, Steuerwald, M, Straumann, A, Sulz, M, Tempia-Caliera, M, Thorens, J, Tutuian, R, Vavricka, S, Velin, D, Viani, F, Von Känel, R, Vonlaufen, A, Vouillamoz, D, Wachter, G, Wermuth, J, Wiesel, P, Zamora, S & Zeitz, J 2013, 'Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease', Digestion, vol. 87, no. 3, pp. 212-221. https://doi.org/10.1159/000350954

TY - JOUR

T1 - Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease

AU - Pittet, Valerie

AU - Rogler, Gerhard

AU - Michetti, Pierre

AU - Fournier, Nicolas

AU - Vader, John Paul

AU - Schoepfer, Alain

AU - Mottet, Christian

AU - Burnand, Bernard

AU - Froehlich, Florian

AU - Bauerfeind, Peter

AU - Beglinger, Christoph

AU - Begré, Stefan

AU - Belli, Dominique

AU - Bengoa, José

AU - Biedermann, Luc

AU - Binek, Janek

AU - Borovicka, Jan

AU - Braegger, Christian

AU - Bühr, Patrick

AU - Burri, Emanuel

AU - Camara, Rafael

AU - Criblez, Dominique

AU - De Saussure, Philippe

AU - Degen, Lukas

AU - Delhavi, Mohamed Ali

AU - Delarive, Joakim

AU - Dörig, Christopher

AU - Dorta, Gian

AU - Ehmann, Tobias

AU - El Wafa, Ali

AU - Felley, Christian

AU - Fliegner, Markus

AU - Frei, Alain

AU - Frei, Pascal

AU - Frei, Remus

AU - Fried, Michael

AU - Friedt, Michael

AU - Frühauf, Heiko

AU - Furlano, Raoul

AU - Gallot-Lavallée, Suzanne

AU - Geyer, Martin

AU - Girardin, Marc

AU - Godat, Sébastien

AU - Gonvers, Jean Jacques

AU - Good, Ignaz

AU - Götze, Oliver

AU - Gysi, Beat

AU - Hadengue, Antoine

AU - Halama, Marcel

AU - Hediger, Serge

AU - Heer, Pius

AU - Helbling, Beat

AU - Hellstern, Mona

AU - Hengstler, Peter

AU - Herzog, Denise

AU - Hess, Cyrill

AU - Heyland, Klaas

AU - Hinterleitner, Thomas

AU - Hiroz, Philippe

AU - Hirschi, Claudia

AU - Hruz, Petr

AU - Janiak, Patrick

AU - Jost, Christian

AU - Juillerat, Pascal

AU - Brondolo, Vera Kessler

AU - Knoblauch, Christoph

AU - Krieger, Claudia

AU - Kullak-Ublick, Gerd A.

AU - Landolt, Markus

AU - Leung-Ki, En Ling

AU - Maerten, Philippe

AU - Maillard, Michel

AU - Manser, Christine

AU - Manz, Michael

AU - Marbet, Urs

AU - Marsteller, Igor

AU - Meier, Rémy

AU - Meyenberger, Christa

AU - Mondada, David

AU - Moradpour, Darius

AU - Mosler, Patrick

AU - Müller, Christoph

AU - Müller, Pascal

AU - Müllhaupt, Beat

AU - Nagy, Andreas

AU - Nichita, Cristina

AU - Nicolet, Thierry

AU - Nüesch, Hansjürg

AU - Nydegger, Andreas

AU - Pache, Isabelle

AU - Piccoli, Franziska

AU - Pilz, Julia

AU - Raffa, Bruno

AU - Rentsch, Ronald

AU - Rey, Jean Pierre

AU - Rogler, Daniela

AU - Sagmeister, Markus

AU - Sauter, Bernhard

AU - Sawatzki, Mikael

AU - Schacher, Gerold

AU - Scharl, Michael

AU - Schaub, Nora

AU - Schellin, Martin

AU - Schibli, Susanne

AU - Schlauri, Hugo

AU - Schnegg, Jean François

AU - Seibold, Franck

AU - Seirafi, Mariam

AU - Semela, David

AU - Sidler, Marc

AU - Spalinger, Johannes

AU - Spangenberger, Holger

AU - Stadler, Philippe

AU - Staub, Peter

AU - Steuerwald, Michael

AU - Straumann, Alex

AU - Sulz, Michael

AU - Tempia-Caliera, Michela

AU - Thorens, Joël

AU - Tutuian, Radu

AU - Vavricka, Stephan

AU - Velin, Dominique

AU - Viani, Francesco

AU - Von Känel, Roland

AU - Vonlaufen, Alain

AU - Vouillamoz, Dominique

AU - Wachter, Gert

AU - Wermuth, Jürg

AU - Wiesel, Paul

AU - Zamora, Samuel

AU - Zeitz, Jonas

PY - 2013/6

Y1 - 2013/6

N2 - Background: About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. Methods: Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. Results: Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). Conclusion: The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.

AB - Background: About 80% of patients with Crohn's disease (CD) require bowel resection and up to 65% will undergo a second resection within 10 years. This study reports clinical risk factors for resection surgery (RS) and repeat RS. Methods: Retrospective cohort study, using data from patients included in the Swiss Inflammatory Bowel Disease Cohort. Cox regression analyses were performed to estimate rates of initial and repeated RS. Results: Out of 1,138 CD cohort patients, 417 (36.6%) had already undergone RS at the time of inclusion. Kaplan-Meier curves showed that the probability of being free of RS was 65% after 10 years, 42% after 20 years, and 23% after 40 years. Perianal involvement (PA) did not modify this probability to a significant extent. The main adjusted risk factors for RS were smoking at diagnosis (hazard ratio (HR) = 1.33; p = 0.006), stricturing with vs. without PA (HR = 4.91 vs. 4.11; p < 0.001) or penetrating disease with vs. without PA (HR = 3.53 vs. 4.58; p < 0.001). The risk factor for repeat RS was penetrating disease with vs. without PA (HR = 3.17 vs. 2.24; p < 0.05). Conclusion: The risk of RS was confirmed to be very high for CD in our cohort. Smoking status at diagnosis, but mostly penetrating and stricturing diseases increase the risk of RS.

KW - Crohn's disease

KW - Epidemiology

KW - Surgery for IBD

UR - http://www.scopus.com/inward/record.url?scp=84878022371&partnerID=8YFLogxK

U2 - 10.1159/000350954

DO - 10.1159/000350954

M3 - Article

C2 - 23711401

AN - SCOPUS:84878022371

SN - 0012-2823

VL - 87

SP - 212

EP - 221

JO - Digestion

JF - Digestion

IS - 3

ER -

Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease

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