Peering into the crystal ball: Influenza pandemics and vaccine efficacy

Matthew S. Miller; Peter Palese

doi:10.1016/j.cell.2014.03.023

Peering into the crystal ball: Influenza pandemics and vaccine efficacy

Matthew S. Miller, Peter Palese

Research output: Contribution to journal › Comment/debate

21 Scopus citations

Abstract

The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?

Original language	English
Pages (from-to)	294-299
Number of pages	6
Journal	Cell
Volume	157
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2014.03.023
State	Published - 10 Apr 2014

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title = "Peering into the crystal ball: Influenza pandemics and vaccine efficacy",

abstract = "The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?",

author = "Miller, {Matthew S.} and Peter Palese",

note = "Funding Information: We apologize to our colleagues whose work could not be cited due to space limitations. M.S.M. is supported, in part, by a Canadian Institutes of Health Research Postdoctoral Fellowship. P.P. is supported, in part, by NIH P01 AI097092-01 and HHSN266200700010C.",

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AU - Palese, Peter

N1 - Funding Information: We apologize to our colleagues whose work could not be cited due to space limitations. M.S.M. is supported, in part, by a Canadian Institutes of Health Research Postdoctoral Fellowship. P.P. is supported, in part, by NIH P01 AI097092-01 and HHSN266200700010C.

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N2 - The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?

AB - The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?

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Peering into the crystal ball: Influenza pandemics and vaccine efficacy

Abstract

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