Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation

Fan Yang, Ying Li, Raul Braylan, Stephen P. Hunger, Li Jun Yang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is the most common treatment related malignancy that occurs after solid organ transplantation (SOT). PTLD has extended from its initial description as an Epstein-Barr virus (EBV)-driven B-cell proliferation to include EBV-negative and non B-lineage cases. T-cell PTLD (T-PTLD) is rare in both adults and children. We report two cases of pediatric T-PTLD after SOT (liver and lungs) and review cases reported in the literature. Both patients had a bimodal response to therapy with initial eradication of bulky nodal disease with regimens typically used to treat leukemia, but persistence of low-level clonal T-cells in marrow, CSF and lung in one case.

Original languageEnglish
Pages (from-to)415-418
Number of pages4
JournalPediatric Blood and Cancer
Volume50
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Flow cytometry
  • T-cell PTLD
  • T-cell receptor V-beta

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