Pediatric renal transplantation under FK-506 immunosuppression

F. X. Schneck, M. L. Jordan, C. W.B. Jensen, R. Shapiro, A. Tzakis, V. P. Scantlebury, D. Ellis, N. Gilboa, R. L. Simmons, T. R. Hakala, T. E. Starzl

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21 Scopus citations

Abstract

Renal transplantation (11 cadaveric and 1 living-related donor) was performed in 12 pediatric recipients (mean age 10.8 years) under FK-506 immunosuppression in combination with prednisone therapy. At a mean followup of 6.1 months, patient and graft survival rates were 100% and 92%, respectively. The only graft loss was due to the recurrent hemolytic uremic syndrome 4 days after transplantation. In the functioning grafts the mean serum creatinine is 1.59 ± 1.27 mg./dl. and the mean blood urea nitrogen is 36.3 ± 24.6 mg./dl. Three patients take no prednisone, 5 are receiving 0.15 to 0.25 mg./kg. per day and 3 are taking 0.35 to 0.5 mg./kg. per day. There was a total of 8 rejection episodes in 5 patients. All rejection episodes were successfully reversed. Complications of transplantation included an episode of seizures in 1 patient, cytomegalovirus infection in 1 and steroid- induced diabetes mellitus in 1. Since pediatric transplant recipients are a group in whom the reduction or elimination of steroids is highly desirable, FK-506 immunosuppression may be particularly suited for use in this population.

Original languageEnglish
Pages (from-to)1585-1587
Number of pages3
JournalJournal of Urology
Volume147
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • immunosuppression
  • immunosuppressive agents
  • kidney transplantation
  • pediatrics

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