Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17

Giulio Kleiner, Valentina Zanin, Lorenzo Monasta, Sergio Crovella, Lorenzo Caruso, Daniela Milani, Annalisa Marcuzzi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of the gastrointestinal tract. Although the causative events that lead to the onset of IBD are yet to be fully elucidated, deregulation of immune and inflammatory mechanisms are hypothesized to significantly contribute to this disorder. Since the onset of IBD is often during infancy, in the present study, the serum values of a large panel of cytokines and chemokines in pediatric patients (<18 years; n=26) were compared with age-matched controls (n=37). While elevations in the serum level of several proinflammatory and immune regulating cytokines were confirmed, such as interleukin (IL)-1β, IL-5, IL-7, interferon (IFN)-γ-inducible protein-10, IL-16, cutaneous T-cell-attracting chemokine, leukemia inhibitory factor, monokine induced by γ-IFN, IFN-α2 and IFN-γ, notably decreased levels of IL-2, IL-17 and macrophage inhibitory protein-1β were also observed. Therefore, while a number of proinflammatory cytokines exhibit increased levels in IBD patients, pediatric IBD patients may also exhibit certain aspects of a reduced immunological response.

Original languageEnglish
Pages (from-to)2047-2052
Number of pages6
JournalExperimental and Therapeutic Medicine
Volume9
Issue number6
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Chemokines
  • Cytokines
  • Inflammatory bowel disease

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