@article{6b9d631ad9ea4d939fab3830d793743e,
title = "PDGF signaling specificity is mediated through multiple immediate early genes",
abstract = "Growth factor signaling leads to the induction or repression of immediate early genes, but how these genes act collectively as effectors of downstream processes remains unresolved. We have used gene trap-coupled microarray analysis to identify and mutate multiple platelet-derived growth factor (PDGF) intermediate early genes in mice. Mutations in these genes lead to a high frequency of phenotypes that affect the same cell types and processes as those controlled by the PDGF pathway. We conclude that these genes form a network that controls specific processes downstream of PDGF signaling.",
author = "Jennifer Schmahl and Raymond, \{Christopher S.\} and Philippe Soriano",
note = "Funding Information: We thank P. Corrin and M. Grenley for excellent technical assistance; B. Hoplight for assistance with statistical analysis and our laboratory colleagues S. Parkhurst and M. Van Gilst for critical reading of the manuscript. The Sox10 probe was a gift of M. Wegner (Universit{\"a}t Erlangen). J.S. and C.S.R. were the recipients of postdoctoral fellowships from the US National Institute of General Medical Sciences (GM071158) and from the Leukemia and Lymphoma Society, respectively, and both were supported by a Chromosome and Metabolism Training Grant (CA09657). This work was supported by grant HD24875 from the National Institute of Child Health and Human Development to P.S.",
year = "2007",
month = jan,
doi = "10.1038/ng1922",
language = "English",
volume = "39",
pages = "52--60",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "1",
}