PC-SPES and prostate cancer

William K. Oh; Eric J. Small

doi:10.1016/S0094-0143(02)00017-4

PC-SPES and prostate cancer

William K. Oh, Eric J. Small

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Urologic Clinics of North America
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/S0094-0143(02)00017-4
State	Published - 2002
Externally published	Yes

Access to Document

10.1016/S0094-0143(02)00017-4

Cite this

@article{54798425738a4dce9cbab22cce2cd77a,

title = "PC-SPES and prostate cancer",

abstract = "PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5\% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.",

author = "Oh, \{William K.\} and Small, \{Eric J.\}",

year = "2002",

doi = "10.1016/S0094-0143(02)00017-4",

language = "English",

volume = "29",

pages = "59--66",

journal = "Urologic Clinics of North America",

issn = "0094-0143",

publisher = "W.B. Saunders",

number = "1",

}

TY - JOUR

T1 - PC-SPES and prostate cancer

AU - Oh, William K.

AU - Small, Eric J.

PY - 2002

Y1 - 2002

N2 - PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.

AB - PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.

UR - https://www.scopus.com/pages/publications/0036301667

U2 - 10.1016/S0094-0143(02)00017-4

DO - 10.1016/S0094-0143(02)00017-4

M3 - Review article

C2 - 12109356

AN - SCOPUS:0036301667

SN - 0094-0143

VL - 29

SP - 59

EP - 66

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 1

ER -

PC-SPES and prostate cancer

Abstract

Access to Document

Fingerprint

Cite this