PC-SPES and prostate cancer

William K. Oh; Eric J. Small

doi:10.1016/S0094-0143(02)00017-4

PC-SPES and prostate cancer

William K. Oh, Eric J. Small

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Urologic Clinics of North America
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/S0094-0143(02)00017-4
State	Published - 2002
Externally published	Yes

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title = "PC-SPES and prostate cancer",

abstract = "PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.",

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AU - Oh, William K.

AU - Small, Eric J.

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AB - PC-SPES (Botanic Lab, Brea, CA) is a combination of eight herbal therapies with activity against prostate cancer, both in vitro and in vivo. Studies in human prostate cancer cell lines demonstrate significant dose-dependent decreases in cellular viability after exposure to extracts of PC-SPES. Clinical studies suggest that PC-SPES can reduce specific antigen levels in both androgen-dependent and androgen-independent prostate cancer patients. Toxicity is mild, thought there is an approximately 5% risk of thromboembolic events with treatment. Although PC-SPES has apparent estrogenic activity, controversy exists over the exact mechanism of its effects.

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DO - 10.1016/S0094-0143(02)00017-4

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JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

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PC-SPES and prostate cancer

Abstract

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