PAX-5 expression in pulmonary neuroendocrine neoplasms: Its usefulness in surgical and fine-needle aspiration biopsy specimens

Gabriel Sica, Madeline F. Vazquez, Nassar Altorki, Jeffrey Port, Paul C. Lee, Yifang Liu, Elizabeth Hyjek, Anjali Saqi

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The World Health Organization classification of lung tumors recognizes 4 histologic subtypes of pulmonary neuroendocrine carcinomas (NECs), which include typical carcinoids (TCs), atypical carcinoids (ACs), small cell carcinomas (SCCs), and large cell NECs (LCNECs). These tumors can be misclassified owing to morphologic parallels, indicating the necessity for adjunctive tests for correct classification. We evaluated immunohistochemical expression of PAX-5 in histologic and fine-needle aspiration (FNA) specimens of pulmonary NECs. Staining was stratified by intensity (0 to 3+) and percentage of cells stained as focal (<10%) or diffuse (≥10%). PAX-5 expression was present in 29/37 (78%) of high-grade NECs (22/26 SCCs, 1/2 LCNECs, and 6/9 combined tumors) and none of 51 TCs and ACs; FNA specimens showed concordant staining. This study confirmed that PAX-5 is a useful marker in FNA and surgical specimens for the discrimination of low- to intermediate-grade NECs from high-grade NECs with 100% specificity and 79% sensitivity in surgical specimens.

Original languageEnglish
Pages (from-to)556-562
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume129
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Carcinoid
  • Large cell neuroendocrine carcinoma
  • Lung carcinoma
  • PAX-5
  • Small cell carcinoma

Fingerprint

Dive into the research topics of 'PAX-5 expression in pulmonary neuroendocrine neoplasms: Its usefulness in surgical and fine-needle aspiration biopsy specimens'. Together they form a unique fingerprint.

Cite this