Patterns of use of hemostatic agents in patients undergoing major surgery

Jason D. Wright, Cande V. Ananth, Sharyn N. Lewin, William M. Burke, Zainab Siddiq, Alfred I. Neugut, Thomas J. Herzog, Dawn L. Hershman

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42 Scopus citations


Background Although a number of prohemostatic agents that are applied intraoperatively have been introduced to minimize bleeding, little is known about the patterns of use and the factors that influence use. We examined the use of hemostatic agents in patients undergoing major surgery. Methods All patients who underwent major general, gynecologic, urologic, cardiothoracic, or orthopedic surgery from 2000-2010 who were recorded in the Perspective database were analyzed. Results Among 3,633,799 patients, hemostatic agents were used in 30.3% (n = 1,102,267). The use of hemostatic agents increased from 28.5% in 2000 to 35.2% in 2010. Over the same period, the rates of transfusion declined for pancreatectomy (-14.4%), liver resection (-15.0%), gastrectomy (-11.7%), prostatectomy (-6.6%), nephrectomy (-4.6%), hip arthroplasty (-10.4%), and knee arthroplasty (-6.6%). Over the same time period, the transfusion rate increased for colectomy (6.0%), hysterectomy (3.7%), coronary artery bypass graft (8.4%), valvuloplasty (4.2%), lung resection (1.9%), and spine surgery (1.6%). Transfusion remained relatively stable for thyroidectomy (0.2%). Conclusions The use of hemostatic agents has increased rapidly even for surgeries associated with a small risk of transfusion and bleeding complications. In addition to patient characteristics, surgeon and hospital factors exerted substantial influence on the allocation of hemostatic agents.

Original languageEnglish
Pages (from-to)458-466
Number of pages9
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 2014
Externally publishedYes


  • Bleeding
  • Blood
  • Hemorrhage
  • Hemostasis
  • Hemostatic agents


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