Patterns of metabolic activity in the treatment of schizophrenia

Jonathan D. Brodie; David R. Christman; Juan F. Corona; Joanna S. Fowler; Francisco Gomez‐Mont; Judith Jaeger; Peter A. Micheels; John Rotrosen; Jerome A. Russell; Nora D. Volkow; Alan Wikler; Alfred P. Wolf; Adam Wolkin

doi:10.1002/ana.410150731

Patterns of metabolic activity in the treatment of schizophrenia

Jonathan D. Brodie, David R. Christman, Juan F. Corona, Joanna S. Fowler, Francisco Gomez‐Mont, Judith Jaeger, Peter A. Micheels, John Rotrosen, Jerome A. Russell, Nora D. Volkow, Alan Wikler, Alfred P. Wolf, Adam Wolkin

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Six patients with chronic schizophrenia were studied with positron emission tomography (PET) before and after neuroleptic treatment, using fluorine‐18‐labeled fluorodeoxyglucose. After treatment, the mean whole‐slice glucose metabolic rate at the level of the basal ganglia showed a 25% increase. However, patterns of frontal hypometabolism observed with the schizophrenic patients were not altered by medication. Pattern analysis using the fast fourier transform was applied to a set of 422 images from a mixed group of norma, depressed, and schizophrenic subjects. Reconstruction of the images with low‐frequency coefficients was excellent, reducing considerably the number of variables needed to characterize each image. Hierarchical cluster analysis categorized the transformed images according to anatomical level and subject group (patient versus control). The results suggest the utility of this procedure for the classification and characterization of metabolic PET images from psychiatric patients.

Original language	English
Pages (from-to)	166-169
Number of pages	4
Journal	Annals of Neurology
Volume	15
Issue number	1 S
DOIs	https://doi.org/10.1002/ana.410150731
State	Published - 1984
Externally published	Yes

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title = "Patterns of metabolic activity in the treatment of schizophrenia",

abstract = "Six patients with chronic schizophrenia were studied with positron emission tomography (PET) before and after neuroleptic treatment, using fluorine‐18‐labeled fluorodeoxyglucose. After treatment, the mean whole‐slice glucose metabolic rate at the level of the basal ganglia showed a 25\% increase. However, patterns of frontal hypometabolism observed with the schizophrenic patients were not altered by medication. Pattern analysis using the fast fourier transform was applied to a set of 422 images from a mixed group of norma, depressed, and schizophrenic subjects. Reconstruction of the images with low‐frequency coefficients was excellent, reducing considerably the number of variables needed to characterize each image. Hierarchical cluster analysis categorized the transformed images according to anatomical level and subject group (patient versus control). The results suggest the utility of this procedure for the classification and characterization of metabolic PET images from psychiatric patients.",

author = "Brodie, \{Jonathan D.\} and Christman, \{David R.\} and Corona, \{Juan F.\} and Fowler, \{Joanna S.\} and Francisco Gomez‐Mont and Judith Jaeger and Micheels, \{Peter A.\} and John Rotrosen and Russell, \{Jerome A.\} and Volkow, \{Nora D.\} and Alan Wikler and Wolf, \{Alfred P.\} and Adam Wolkin",

year = "1984",

doi = "10.1002/ana.410150731",

language = "English",

volume = "15",

pages = "166--169",

journal = "Annals of Neurology",

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publisher = "John Wiley \& Sons Inc.",

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TY - JOUR

T1 - Patterns of metabolic activity in the treatment of schizophrenia

AU - Brodie, Jonathan D.

AU - Christman, David R.

AU - Corona, Juan F.

AU - Fowler, Joanna S.

AU - Gomez‐Mont, Francisco

AU - Jaeger, Judith

AU - Micheels, Peter A.

AU - Rotrosen, John

AU - Russell, Jerome A.

AU - Volkow, Nora D.

AU - Wikler, Alan

AU - Wolf, Alfred P.

AU - Wolkin, Adam

PY - 1984

Y1 - 1984

N2 - Six patients with chronic schizophrenia were studied with positron emission tomography (PET) before and after neuroleptic treatment, using fluorine‐18‐labeled fluorodeoxyglucose. After treatment, the mean whole‐slice glucose metabolic rate at the level of the basal ganglia showed a 25% increase. However, patterns of frontal hypometabolism observed with the schizophrenic patients were not altered by medication. Pattern analysis using the fast fourier transform was applied to a set of 422 images from a mixed group of norma, depressed, and schizophrenic subjects. Reconstruction of the images with low‐frequency coefficients was excellent, reducing considerably the number of variables needed to characterize each image. Hierarchical cluster analysis categorized the transformed images according to anatomical level and subject group (patient versus control). The results suggest the utility of this procedure for the classification and characterization of metabolic PET images from psychiatric patients.

AB - Six patients with chronic schizophrenia were studied with positron emission tomography (PET) before and after neuroleptic treatment, using fluorine‐18‐labeled fluorodeoxyglucose. After treatment, the mean whole‐slice glucose metabolic rate at the level of the basal ganglia showed a 25% increase. However, patterns of frontal hypometabolism observed with the schizophrenic patients were not altered by medication. Pattern analysis using the fast fourier transform was applied to a set of 422 images from a mixed group of norma, depressed, and schizophrenic subjects. Reconstruction of the images with low‐frequency coefficients was excellent, reducing considerably the number of variables needed to characterize each image. Hierarchical cluster analysis categorized the transformed images according to anatomical level and subject group (patient versus control). The results suggest the utility of this procedure for the classification and characterization of metabolic PET images from psychiatric patients.

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VL - 15

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 1 S

ER -

Patterns of metabolic activity in the treatment of schizophrenia

Abstract

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