Patterns of Endogenous Platelet Serotonin Release

L. M. Aledort; H. S. Gilbert; E. Puszkin

doi:10.1111/j.1537-2995.1971.tb04413.x

Patterns of Endogenous Platelet Serotonin Release

L. M. Aledort, H. S. Gilbert, E. Puszkin

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4 Scopus citations

Abstract

The release of endogenous serotonin (5HT) from the platelets of normal human subjects was studied using adenosine diphosphate (ADP), thrombin, and connective tissue (CT) as aggregating agents. Clot retraction was found to release from 60 to 100 per cent of available platelet 5HT. Of the aggregating agents studied, only connective tissue was accompanied by the release of endogenous SHT in all subjects. Low concentrations of ADP gave no release, and high concentrations of ADP as well as thrombin‐induced aggregation gave release in the minority of subjects. The pattern of release of endogenous 5HT in response to aggregating agents was found to differ from results of studies reported by others 18, 19 using exogenous radioactive 5HT. 1971 AABB

Original language	English
Pages (from-to)	266-269
Number of pages	4
Journal	Transfusion
Volume	11
Issue number	5
DOIs	https://doi.org/10.1111/j.1537-2995.1971.tb04413.x
State	Published - 1971
Externally published	Yes

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abstract = "The release of endogenous serotonin (5HT) from the platelets of normal human subjects was studied using adenosine diphosphate (ADP), thrombin, and connective tissue (CT) as aggregating agents. Clot retraction was found to release from 60 to 100 per cent of available platelet 5HT. Of the aggregating agents studied, only connective tissue was accompanied by the release of endogenous SHT in all subjects. Low concentrations of ADP gave no release, and high concentrations of ADP as well as thrombin‐induced aggregation gave release in the minority of subjects. The pattern of release of endogenous 5HT in response to aggregating agents was found to differ from results of studies reported by others 18, 19 using exogenous radioactive 5HT. 1971 AABB",

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AU - Aledort, L. M.

AU - Gilbert, H. S.

AU - Puszkin, E.

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N2 - The release of endogenous serotonin (5HT) from the platelets of normal human subjects was studied using adenosine diphosphate (ADP), thrombin, and connective tissue (CT) as aggregating agents. Clot retraction was found to release from 60 to 100 per cent of available platelet 5HT. Of the aggregating agents studied, only connective tissue was accompanied by the release of endogenous SHT in all subjects. Low concentrations of ADP gave no release, and high concentrations of ADP as well as thrombin‐induced aggregation gave release in the minority of subjects. The pattern of release of endogenous 5HT in response to aggregating agents was found to differ from results of studies reported by others 18, 19 using exogenous radioactive 5HT. 1971 AABB

AB - The release of endogenous serotonin (5HT) from the platelets of normal human subjects was studied using adenosine diphosphate (ADP), thrombin, and connective tissue (CT) as aggregating agents. Clot retraction was found to release from 60 to 100 per cent of available platelet 5HT. Of the aggregating agents studied, only connective tissue was accompanied by the release of endogenous SHT in all subjects. Low concentrations of ADP gave no release, and high concentrations of ADP as well as thrombin‐induced aggregation gave release in the minority of subjects. The pattern of release of endogenous 5HT in response to aggregating agents was found to differ from results of studies reported by others 18, 19 using exogenous radioactive 5HT. 1971 AABB

UR - https://www.scopus.com/pages/publications/0015125929

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AN - SCOPUS:0015125929

SN - 0041-1132

VL - 11

SP - 266

EP - 269

JO - Transfusion

JF - Transfusion

IS - 5

ER -

Patterns of Endogenous Platelet Serotonin Release

Abstract

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