Patients at Risk for AIDS-Related Opportunistic Infections: Clinical Manifestations and Impaired Gamma Interferon Production

Henry W. Murray; Janice K. Hillman; Berish Y. Rubin; Catherine D. Kelly; Jonathan L. Jacobs; Lisa W. Tyler; Daria M. Donelly; Susan M. Carriero; James H. Godbold; Richard B. Roberts

doi:10.1056/NEJM198512123132403

Patients at Risk for AIDS-Related Opportunistic Infections: Clinical Manifestations and Impaired Gamma Interferon Production

Henry W. Murray
, Janice K. Hillman
, Berish Y. Rubin
, Catherine D. Kelly
, Jonathan L. Jacobs
, Lisa W. Tyler
, Daria M. Donelly
, Susan M. Carriero
, James H. Godbold
, Richard B. Roberts

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

AMONG the numerous T-cell defects identified in patients with the acquired immunodeficiency syndrome (AIDS),¹ the failure to generate gamma interferon² seems likely for several reasons to be relevant to the immunopathogenesis of AIDS-related opportunistic infections. For example, gamma interferon is probably the key T-cell-derived lymphokine that induces macrophages and other potential host defense cells to exert enhanced antimicrobial activity against both intracellular and extracellular pathogens.³ ⁴ ⁵ ⁶ ⁷ ⁸ ⁹ ¹⁰ In addition, gamma interferon also appears to have a pivotal regulatory role in a variety of other cellular immune reactions,¹¹ including those involved in antigen-stimulated T-cell activation.¹² ¹³ ¹⁴ ¹⁵ Given this background and the earlier demonstration that.

Original language	English
Pages (from-to)	1504-1510
Number of pages	7
Journal	New England Journal of Medicine
Volume	313
Issue number	24
DOIs	https://doi.org/10.1056/NEJM198512123132403
State	Published - 12 Dec 1985
Externally published	Yes

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Murray, H. W., Hillman, J. K., Rubin, B. Y., Kelly, C. D., Jacobs, J. L., Tyler, L. W., Donelly, D. M., Carriero, S. M., Godbold, J. H., & Roberts, R. B. (1985). Patients at Risk for AIDS-Related Opportunistic Infections: Clinical Manifestations and Impaired Gamma Interferon Production. New England Journal of Medicine, 313(24), 1504-1510. https://doi.org/10.1056/NEJM198512123132403

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title = "Patients at Risk for AIDS-Related Opportunistic Infections: Clinical Manifestations and Impaired Gamma Interferon Production",

abstract = "AMONG the numerous T-cell defects identified in patients with the acquired immunodeficiency syndrome (AIDS),1 the failure to generate gamma interferon2 seems likely for several reasons to be relevant to the immunopathogenesis of AIDS-related opportunistic infections. For example, gamma interferon is probably the key T-cell-derived lymphokine that induces macrophages and other potential host defense cells to exert enhanced antimicrobial activity against both intracellular and extracellular pathogens.3 4 5 6 7 8 9 10 In addition, gamma interferon also appears to have a pivotal regulatory role in a variety of other cellular immune reactions,11 including those involved in antigen-stimulated T-cell activation.12 13 14 15 Given this background and the earlier demonstration that.",

author = "Murray, \{Henry W.\} and Hillman, \{Janice K.\} and Rubin, \{Berish Y.\} and Kelly, \{Catherine D.\} and Jacobs, \{Jonathan L.\} and Tyler, \{Lisa W.\} and Donelly, \{Daria M.\} and Carriero, \{Susan M.\} and Godbold, \{James H.\} and Roberts, \{Richard B.\}",

year = "1985",

month = dec,

day = "12",

doi = "10.1056/NEJM198512123132403",

language = "English",

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T2 - Clinical Manifestations and Impaired Gamma Interferon Production

AU - Murray, Henry W.

AU - Hillman, Janice K.

AU - Rubin, Berish Y.

AU - Kelly, Catherine D.

AU - Jacobs, Jonathan L.

AU - Tyler, Lisa W.

AU - Donelly, Daria M.

AU - Carriero, Susan M.

AU - Godbold, James H.

AU - Roberts, Richard B.

PY - 1985/12/12

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AB - AMONG the numerous T-cell defects identified in patients with the acquired immunodeficiency syndrome (AIDS),1 the failure to generate gamma interferon2 seems likely for several reasons to be relevant to the immunopathogenesis of AIDS-related opportunistic infections. For example, gamma interferon is probably the key T-cell-derived lymphokine that induces macrophages and other potential host defense cells to exert enhanced antimicrobial activity against both intracellular and extracellular pathogens.3 4 5 6 7 8 9 10 In addition, gamma interferon also appears to have a pivotal regulatory role in a variety of other cellular immune reactions,11 including those involved in antigen-stimulated T-cell activation.12 13 14 15 Given this background and the earlier demonstration that.

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DO - 10.1056/NEJM198512123132403

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JO - New England Journal of Medicine

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Patients at Risk for AIDS-Related Opportunistic Infections: Clinical Manifestations and Impaired Gamma Interferon Production

Abstract

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