Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms

Silvana Wilken, Tharusan Thevathasan, Can Kamali, Adrien Guillot, Jana Ihlow, Uli Fehrenbach, Magdalena Danyel, Johann Pratschke, Frank Tacke, Felix Krenzien

Research output: Contribution to journalArticlepeer-review


Simultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalClinical Journal of Gastroenterology
Issue number2
StatePublished - Apr 2024
Externally publishedYes


  • Benign liver tumor
  • Focal nodular hyperplasia
  • Hepatic hemangioma
  • Hepatocellular adenoma


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