Patient-specific analysis of bicuspid aortic valve hemodynamics using a fully coupled fluid-structure interaction model

Tongran Qin, Wenbin Mao, Andrés Caballero, Norihiko Kamioka, Stamatios Lerakis, Santiago Lain, John Elefteriades, Liang Liang, Wei Sun

Research output: Contribution to journalArticlepeer-review


Bicuspid aortic valve (BAV), the most common congenital heart disease, is prone to develop significant valvular dysfunction and aortic wall abnormalities such as ascending aortic aneurysm. Growing evidence has suggested that abnormal BAV hemodynamics could contribute to disease progression. In order to investigate BAV hemodynamics, we performed 3D patient-specific fluid-structure interaction (FSI) simulations with fully coupled blood flow dynamics and valve motion throughout the cardiac cycle. Results showed that the hemodynamics during systole can be characterized by a systolic jet and two counter-rotating recirculation vortices. At peak systole, the jet was usually eccentric, with asymmetric recirculation vortices and helical flow motion in the ascending aorta. The flow structure at peak systole was quantified using the vorticity, flow rate reversal ratio and local normalized helicity (LNH) at four locations from the aortic root to the ascending aorta. The systolic jet was evaluated with the peak velocity, normalized flow displacement, and jet angle. It was found that peak velocity and normalized flow displacement (rather than jet angle) gave a strong correlation with the vorticity and LNH in the ascending aorta, which suggests that these two metrics could be used for clinical noninvasive evaluation of abnormal blood flow patterns in BAV patients.

Original languageEnglish
Article number108191
JournalComputers in Biology and Medicine
StatePublished - Apr 2024


  • Aortic disease
  • Ascending aorta
  • Bicuspid aortic valve
  • Fluid-structure interaction
  • Helical flow
  • Hemodynamics
  • Patient-specific modeling


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