Patient selection critical for calcineurin inhibitor withdrawal in pediatric kidney transplantation

Lauren Weintraub, Li Li, Neeraja Kambham, Steven Alexander, Waldo Concepcion, Kim Miller, Cynthia Wong, Oscar Salvatierra, Minnie Sarwal

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

CNI withdrawal may be employed as a rescue strategy for patients with established renal allograft injury and/or declining allograft function, with the aim at eliminating CNI-associated nephrotoxic effects. This analysis reviews outcomes in a pediatric population and identifies risk factors for adverse events post-CNI withdrawal. We performed a retrospective analysis of 17 pediatric renal transplants who underwent CNI withdrawal, with conversion to sirolimus and MMF. Mean CrCl decreased from 64.3 ± 22 to 59.38 ± 28.6 mL/min/ 1.73 m 2 (p = 0.04) at six months and 57.46 ± 31.1 mL/min/1.73 m 2 (p = 0.02) at 12 months post-withdrawal. Forty-one percent of patients experienced AR. Increased risk for AR was associated with prior AR history, lower sirolimus trough levels, and lower CNIT biopsy scores. Graft loss (24%) was associated with worse CrCl, proteinuria, and histologic chronicity. Proteinuria (spot protein/creatinine ratio) increased from 0.75 ± 1.0 to 1.71 ± 2.0 (p = 0.03), unrelated to de novo sirolimus use. Four patients returned to CNI-based immunosuppression due to AR (n = 3) and gastrointestinal side effects (n = 1). Careful selection of pediatric candidates for CNI withdrawal is recommended. Worsening graft function and graft loss may be minimized by selecting patients with high CNIT scores and low biopsy chronicity and excluding patients with prior AR history.

Original languageEnglish
Pages (from-to)541-549
Number of pages9
JournalPediatric Transplantation
Volume12
Issue number5
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Calcineurin inhibitors
  • Pediatric renal transplantation
  • Sirolimus
  • acute rejection

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