Patient-reported outcome measures for pediatric psoriasis: A systematic review and critical appraisal from international dermatology outcome measures (IDEOM)

Nicole Salame, Josefina Torres, Jeena Sandhu, Kristina Callis Duffin, Amit Garg, Alice B. Gottlieb, John Latella, Joseph F. Merola, April W. Armstrong

Research output: Contribution to journalReview articlepeer-review

Abstract

Childhood onset psoriasis has a profound impact on the development and quality of life of pediatric patients. Consequently, validated patient-reported outcome measures (PROMs) for pediatric psoriasis are vital to patient care. We sought to critically appraise the literature on the measurement properties of PROMs used in the pediatric psoriasis population. We performed a 2-stage systematic literature synthesis in MEDLINE (1950-2017) and EMBASE (1947-2017) to identify PROMs and studies evaluating their measurement properties. Analysis of studies followed the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology to inform a best evidence synthesis. From 1,128 articles, we identified 29 PROMs. Subsequently, we identified 8 studies evaluating the measurement properties of 7 instruments. Among these instruments, the Simplified Psoriasis Index (SPI) achieved a positive rating for criterion validity, the Dutch version of the Children's Dermatology Life Quality Index (CDLQI) achieved a positive rating for hypothesis testing, and the Swedish version of the CDLQI achieved a negative rating for hypothesis testing. All other assessed measurement properties received indeterminate or unknown ratings due to flaws in study design. PROMs are paramount to the management of pediatric psoriasis. This synthesis emphasizes the critical need for additional studies to further describe the measurement properties of PROMs used in pediatric psoriasis and identify validated, standardized measures for use in clinical practice and research.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalDermatology
Volume234
Issue number3-4
DOIs
StatePublished - 1 Sep 2018
Externally publishedYes

Keywords

  • Juvenile psoriasis
  • Measurement properties
  • Outcome measures
  • Patient-reported outcome measures
  • Patient-reported outcomes
  • Pediatric dermatology
  • Pediatric psoriasis
  • Psoriasis
  • Psychometrics

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