TY - JOUR
T1 - Patient Preferences for Lung Cancer Treatment
T2 - A Qualitative Study Protocol Among Advanced Lung Cancer Patients
AU - Durosini, Ilaria
AU - Janssens, Rosanne
AU - Arnou, Reinhard
AU - Veldwijk, Jorien
AU - Smith, Meredith Y.
AU - Monzani, Dario
AU - Smith, Ian
AU - Galli, Giulia
AU - Garassino, Marina
AU - Katz, Eva G.
AU - Bailo, Luca
AU - Louis, Evelyne
AU - Vandevelde, Marie
AU - Nackaerts, Kristiaan
AU - de Wit, G. Ardine
AU - Pravettoni, Gabriella
AU - Huys, Isabelle
N1 - Publisher Copyright:
© Copyright © 2021 Durosini, Janssens, Arnou, Veldwijk, Smith, Monzani, Smith, Galli, Garassino, Katz, Bailo, Louis, Vandevelde, Nackaerts, de Wit, Pravettoni and Huys.
PY - 2021/2/5
Y1 - 2021/2/5
N2 - Introduction: Lung cancer is the deadliest and most prevalent cancer worldwide. Lung cancer treatments have different characteristics and are associated with a range of benefits and side effects for patients. Such differences may raise uncertainty among drug developers, regulators, payers, and clinicians regarding the value of these treatment effects to patients. The value of conducting patient preference studies (using qualitative and/or quantitative methods) for benefits and side effects of different treatment options has been recognized by healthcare stakeholders, such as drug developers, regulators, health technology assessment bodies, and clinicians. However, evidence-based guidelines on how and when to conduct and use these studies in drug decision-making are lacking. As part of the Innovative Medicines Initiative PREFER project, we developed a protocol for a qualitative study that aims to understand which treatment characteristics are most important to lung cancer patients and to develop attributes and levels for inclusion in a subsequent quantitative preference survey. Methods: The study protocol specifies a four-phased approach: (i) a scoping literature review of published literature, (ii) four focus group discussions with stage III and IV Non-Small Cell Lung Cancer patients, (iii) two nominal group discussions with stage III and IV Non-Small Cell Lung Cancer patients, and (iv) multi-stakeholder discussions involving clinicians and preference experts. Discussion: This protocol outlines methodological and practical steps as to how qualitative research can be applied to identify and develop attributes and levels for inclusion in patient preference studies aiming to inform decisions across the drug life cycle. The results of this study are intended to inform a subsequent quantitative preference survey that assesses patient trade-offs regarding lung cancer treatment options. This protocol may assist researchers, drug developers, and decision-makers in designing qualitative studies to understand which treatment aspects are most valued by patients in drug development, regulation, and reimbursement.
AB - Introduction: Lung cancer is the deadliest and most prevalent cancer worldwide. Lung cancer treatments have different characteristics and are associated with a range of benefits and side effects for patients. Such differences may raise uncertainty among drug developers, regulators, payers, and clinicians regarding the value of these treatment effects to patients. The value of conducting patient preference studies (using qualitative and/or quantitative methods) for benefits and side effects of different treatment options has been recognized by healthcare stakeholders, such as drug developers, regulators, health technology assessment bodies, and clinicians. However, evidence-based guidelines on how and when to conduct and use these studies in drug decision-making are lacking. As part of the Innovative Medicines Initiative PREFER project, we developed a protocol for a qualitative study that aims to understand which treatment characteristics are most important to lung cancer patients and to develop attributes and levels for inclusion in a subsequent quantitative preference survey. Methods: The study protocol specifies a four-phased approach: (i) a scoping literature review of published literature, (ii) four focus group discussions with stage III and IV Non-Small Cell Lung Cancer patients, (iii) two nominal group discussions with stage III and IV Non-Small Cell Lung Cancer patients, and (iv) multi-stakeholder discussions involving clinicians and preference experts. Discussion: This protocol outlines methodological and practical steps as to how qualitative research can be applied to identify and develop attributes and levels for inclusion in patient preference studies aiming to inform decisions across the drug life cycle. The results of this study are intended to inform a subsequent quantitative preference survey that assesses patient trade-offs regarding lung cancer treatment options. This protocol may assist researchers, drug developers, and decision-makers in designing qualitative studies to understand which treatment aspects are most valued by patients in drug development, regulation, and reimbursement.
KW - drug decision-making
KW - drug development
KW - focus group discussion
KW - lung cancer
KW - nominal group technique
KW - patient involvement
KW - patient preferences
KW - patient-centered research
UR - http://www.scopus.com/inward/record.url?scp=85101631247&partnerID=8YFLogxK
U2 - 10.3389/fpubh.2021.622154
DO - 10.3389/fpubh.2021.622154
M3 - Article
C2 - 33634069
AN - SCOPUS:85101631247
SN - 2296-2565
VL - 9
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 622154
ER -