Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

Wenxiang Hu, Chunjie Jiang, Dongyin Guan, Pieterjan Dierickx, Rong Zhang, Arden Moscati, Girish N. Nadkarni, David J. Steger, Ruth J.F. Loos, Cheng Hu, Weiping Jia, Raymond E. Soccio, Mitchell A. Lazar

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Hu, Jiang, et al. utilize patient adipose stem cell-derived adipocytes to reveal SNPs that modulate the effects of antidiabetic drugs by controlling genomic binding of PPARγ.

Original languageEnglish
Pages (from-to)299-308.e6
JournalCell Stem Cell
Volume24
Issue number2
DOIs
StatePublished - 7 Feb 2019

Keywords

  • ABCA1
  • PPARγ
  • adipocytes
  • adipose stem cell
  • antidiabetic drug
  • drug response
  • genetic variation
  • rosiglitazone

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