Pathophysiology of peripheral arterial disease and risk factors for its development

John R. Bartholomew, Jeffrey W. Olin

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Peripheral arterial disease (PAD) is a systemicatherosclerotic process for which the major riskfactors are similar to those for atherosclerosis inthe carotid, coronary, and other vascular beds. Among the traditional risk factors for PAD, thosewith the strongest associations are advanced age, smoking, and diabetes mellitus. More recently, a number of nontraditional risk factors for PAD have also been recognized. This article briefly reviews the pathophysiology of PAD and the evidence supporting established and emerging risk factors forits development.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalCleveland Clinic Journal of Medicine
Issue numberSUPPL.4
StatePublished - 2006


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