Pathophysiology of Celiac Disease

Sonia S. Kupfer, Bana Jabri

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations

Abstract

Celiac disease results from the interplay of genetic, environmental, and immunologic factors. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. This review describes seminal findings in each of the 3 domains of the pathogenesis of celiac disease, namely genetics, environmental triggers, and immune dysregulation, with a focus on newer areas of investigation such as non-HLA genetic variants, the intestinal microbiome, and the role of the innate immune system.

Original languageEnglish
Pages (from-to)639-660
Number of pages22
JournalGastrointestinal Endoscopy Clinics of North America
Volume22
Issue number4
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Adaptive and innate immunity
  • Celiac disease
  • Deamidation
  • Gluten
  • HLA-DQ2 and HLA-DQ8
  • Intestinal microbiome
  • Single-nucleotide polymorphisms

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