Pathology of head and neck cancer I: Epithelial and related tumors

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations


Over 90% of head & neck cancers are squamous cell carcinomas. This presents both advantages and challenges to clinicians and researchers. The frequency of squamous cell carcinoma allows most otolaryngologists to become very familiar with range of clinical presentations and current treatment options for this disease. New treatment protocols can be evaluated with a large patient base. Archival material (banked tissues, datasets) facilitates investigations into the molecular basis of these tumors. The wide range of other tumors arising in the head & neck are therefore relatively infrequent, leading to uncertainty in diagnosis, treatment and opportunities for meaningful research. In this chapter we begin with squamous cell carcinoma and its histologic variants, linking new findings in molecular pathology with conventional and novel prognostic features. We next consider the evaluation of undifferentiated tumors of the head & neck. Appropriate classification has important prognostic and therapeutic implications. This leads to a consideration of the spectrum of neuroendocrine tumors. The spectrum of tumors arising in salivary glands is as wide as anywhere in the body. We will provide a framework for understanding the diversity of morphologic appearances, and summarize current prognostic features. We finish the chapter with a review of ameloblastoma, the major odontogenic tumor.

Original languageEnglish
Title of host publicationHead & Neck Cancer: Current Perspectives, Advances, and Challenges
PublisherSpringer Netherlands
Number of pages31
ISBN (Electronic)9789400758278
ISBN (Print)940075826X, 9789400758261
StatePublished - 1 Jul 2013
Externally publishedYes


  • Head and Neck Cancer
  • Neuroendocrine carcinoma
  • Salivary gland carcinoma
  • Sinonasal carcinoma
  • Squamous cell carcinoma


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