Pathology of Chronic Hepatitis B and Chronic Hepatitis C

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31 Scopus citations


Histologic evaluation of the liver is a major component in the medical management and treatment algorithm of patients with chronic hepatitis B (HBV) and chronic hepatitis C (HCV). Liver biopsy in these patients remains the gold standard, and decisions on treatment are often predicated on the degree of damage and stage of fibrosis. This article outlines the clinical course and serologic diagnosis of HBV and HCV for the clinician and the pathologist, who together have a close working relationship in managing patients with acute and chronic liver disease. The salient histologic features are elucidated in an attempt to provide the clinician with an understanding of the basic histopathology underlying chronic HCV and HBV.

Original languageEnglish
Pages (from-to)555-575
Number of pages21
JournalClinics in Liver Disease
Issue number4
StatePublished - Nov 2010


  • Chronic hepatitis B
  • Chronic hepatitis C
  • Grade
  • Inflammation
  • Liver pathology
  • Stage of fibrosis


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