@inbook{b1b1fc8184834cb3ae0b628f332d0831,
title = "Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases",
abstract = "Histiocytic disorders represent a group of complex pathologies characterized by the accumulation of histiocytes, an old term for tissue-resident macrophages and dendritic cells. Langerhans cell histiocytosis is the most frequent of histiocytosis in humans and has been thought to arise from the abnormal accumulation of epidermal dendritic cells called Langerhans cells. In this chapter, we discuss the origin and differentiation of Langerhans cells and dendritic cells and present accumulated evidence that suggests that Langerhans cell histiocytosis does not result from abnormal Langerhans cell homeostasis but rather is a consequence of misguided differentiation programs of myeloid dendritic cell precursors. We propose reclassification of Langerhans cell histiocytosis, juvenile xanthogranuloma, and Erdheim-Chester disease as inflammatory myeloid neoplasias.",
keywords = "BRAFV600E, DC differentiation, Dendritic cell lineage, Erdheim-Chester disease, Histiocytic disorders, Juvenile xanthogranuloma, Langerhans cell histiocytosis, Macrophages",
author = "Berres, \{Marie Luise\} and Allen, \{Carl E.\} and Miriam Merad",
note = "Funding Information: The authors would like to thank Dr. M. John Hicks for biopsy images and Dr. Kenneth McClain for critical review and helpful discussions. CEA is supported in part by the National Institutes of Health R01 (CA154489) and has no financial conflicts to disclose. MLB is supported in part by a grant of the German Research Association (Deutsche Forschungsgemeinschaft, BE 4818/1-1). MM is supported by NIH grants CA154947A AI10008 AI089987.",
year = "2013",
doi = "10.1016/B978-0-12-417028-5.00005-3",
language = "English",
series = "Advances in Immunology",
publisher = "Academic Press Inc.",
pages = "127--161",
booktitle = "Advances in Immunology",
address = "United States",
}