Pathogenic role of environmental toxins in immune-mediated liver diseases

Carmen M. Stanca, Jawad Babar, Vineet Singal, Esra Ozdenerol, Joseph A. Odin

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Immune-mediated liver diseases contribute significantly to morbidity and mortality due to liver failure and the need for liver transplantation. The pathogenesis of the immune-mediated chronic liver diseases, primary sclerosing cholangitis, autoimmune hepatitis, and primary biliary cirrhosis, is poorly understood. Genetic susceptibility factors may play a role, but increasing attention is being given to the association between environmental factors and these diseases. The existence of such a relationship is supported by epidemiologic surveys, animal models, and geographic clustering analyses. Unearthing the cause of this association may provide insight into the pathogenesis of immune-mediated chronic liver diseases and autoimmunity.

Original languageEnglish
Pages (from-to)59-68
Number of pages10
JournalJournal of Immunotoxicology
Issue number1
StatePublished - Jan 2008


  • Autoimmune hepatitis
  • Epidemiology
  • Geographic clustering
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis


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