TY - JOUR
T1 - Pathogenesis of early neonatal hypocalcemia
T2 - Studies of serum calcitonin, gastrin, and plasma glucagon
AU - Venkararaman, Pankaja S.
AU - Tsang, Reginald C.
AU - Chen, I. Wen
AU - Sperling, Mark A.
N1 - Funding Information:
Elevated serum calcitonin concentrations have been suggested to be a cause of early neonatal hypocalcemia, j Presented in part at the Society for Pediatric Research, San Francisco, May 3, 1984. Supported in part by Grants 11725 and CRC 00123 from the National Institutes of Health and by Ross Laboratories. Submitted for publication Aug. 22, 1986; accepted Oct. 29, 1986. Reprint requests: Pankaja S. Venkataraman, M.B.B.S., Department of Pediatrics, Neonatal Section, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190.
PY - 1987/4
Y1 - 1987/4
N2 - In 64 maternal-infant pairs, we tested the hypotheses that serum calcitonin, serum gastrin, and plasma glucagon concentrations are elevated in infants at risk for early neonatal hypocalcemia, and that elevated serum gastrin and plasma glucagon result in elevated serum calcitonin and low serum calcium values in neonates. Serum Ca declined significantly in neonates at 24 hours of age, and was inversely correlated with serum calcitonin. Cord serum calcitonin, gastrin, and plasma glucagon concentrations rose significantly at 24 hours of age. Cord calcitonin was significantly higher in preterm compored with term infants, and there was no significant difference between asphyxiated and nonasphyxiated preterm neonates; in term neonates cord calcitonin concentration was inversely correlated with Apgar scores at 1 and 5 minutes. Cord calcitonin was not correlated with cord gastrin or glucagon. Cord and 24-hour gastrin and glucagon values were not related to prematuritly; cord glucagon, but not gastrin, was related to birth asphyxia. We conclude that (1) serum calcitonin, gastrin, and plasma glucagon values rise postnatally; serum calcitonin. concentration does not correlate with the elevated serum gastrin and plasma glucagon values; and at 24 hours of age, decreased serum Ca is correlated with serum calcitonin, and hence calcitonin might play a role in the pathogenesis of early neonatal hypocalcemia.
AB - In 64 maternal-infant pairs, we tested the hypotheses that serum calcitonin, serum gastrin, and plasma glucagon concentrations are elevated in infants at risk for early neonatal hypocalcemia, and that elevated serum gastrin and plasma glucagon result in elevated serum calcitonin and low serum calcium values in neonates. Serum Ca declined significantly in neonates at 24 hours of age, and was inversely correlated with serum calcitonin. Cord serum calcitonin, gastrin, and plasma glucagon concentrations rose significantly at 24 hours of age. Cord calcitonin was significantly higher in preterm compored with term infants, and there was no significant difference between asphyxiated and nonasphyxiated preterm neonates; in term neonates cord calcitonin concentration was inversely correlated with Apgar scores at 1 and 5 minutes. Cord calcitonin was not correlated with cord gastrin or glucagon. Cord and 24-hour gastrin and glucagon values were not related to prematuritly; cord glucagon, but not gastrin, was related to birth asphyxia. We conclude that (1) serum calcitonin, gastrin, and plasma glucagon values rise postnatally; serum calcitonin. concentration does not correlate with the elevated serum gastrin and plasma glucagon values; and at 24 hours of age, decreased serum Ca is correlated with serum calcitonin, and hence calcitonin might play a role in the pathogenesis of early neonatal hypocalcemia.
UR - https://www.scopus.com/pages/publications/0023139928
U2 - 10.1016/S0022-3476(87)80560-7
DO - 10.1016/S0022-3476(87)80560-7
M3 - Article
C2 - 3559810
AN - SCOPUS:0023139928
SN - 0022-3476
VL - 110
SP - 599
EP - 603
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -