Pathogenesis, modulation, and therapy of alzheimer's disease: A perspective on roles of liver-x receptors

Jasminka Štefulj; Ute Panzenboeck; Patrick R. Hof; Goran Šimić

doi:10.2478/s13380-013-0136-z

Pathogenesis, modulation, and therapy of alzheimer's disease: A perspective on roles of liver-x receptors

Jasminka Štefulj, Ute Panzenboeck, Patrick R. Hof, Goran Šimić

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The pathogenesis of Alzheimer's disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

Original language	English
Pages (from-to)	349-356
Number of pages	8
Journal	Translational Neuroscience
Volume	4
Issue number	3
DOIs	https://doi.org/10.2478/s13380-013-0136-z
State	Published - Sep 2013

Keywords

Alzheimer's disease
Amyloid-beta
Cholesterol
LXR agonists
Liver-X receptors
Neurodegeneration
Neuroinflammation
Transgenic mouse models

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@article{8997adc9bec64ab2af8d7a1929dc78dd,

title = "Pathogenesis, modulation, and therapy of alzheimer's disease: A perspective on roles of liver-x receptors",

abstract = "The pathogenesis of Alzheimer's disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.",

keywords = "Alzheimer's disease, Amyloid-beta, Cholesterol, LXR agonists, Liver-X receptors, Neurodegeneration, Neuroinflammation, Transgenic mouse models",

author = "Jasminka {\v S}tefulj and Ute Panzenboeck and Hof, {Patrick R.} and Goran {\v S}imi{\'c}",

note = "Funding Information: Authors{\textquoteright} research is supported by the Croatian Ministry of Science, Education and Sport (grants 098-1081870-2395 and 108-1081870-1942), the Austrian Science Fund (grants W1226-B18 and P24783-B19), the Croatian Science Foundation (grant 09/16) and NIH grant P50 AG005138. All authors participated in writing and the critical review of the manuscript.",

year = "2013",

month = sep,

doi = "10.2478/s13380-013-0136-z",

language = "English",

volume = "4",

pages = "349--356",

journal = "Translational Neuroscience",

issn = "2081-3856",

publisher = "Walter de Gruyter GmbH",

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T2 - A perspective on roles of liver-x receptors

AU - Štefulj, Jasminka

AU - Panzenboeck, Ute

AU - Hof, Patrick R.

AU - Šimić, Goran

N1 - Funding Information: Authors’ research is supported by the Croatian Ministry of Science, Education and Sport (grants 098-1081870-2395 and 108-1081870-1942), the Austrian Science Fund (grants W1226-B18 and P24783-B19), the Croatian Science Foundation (grant 09/16) and NIH grant P50 AG005138. All authors participated in writing and the critical review of the manuscript.

PY - 2013/9

Y1 - 2013/9

N2 - The pathogenesis of Alzheimer's disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

AB - The pathogenesis of Alzheimer's disease (AD) has been mostly linked to aberrant amyloid beta (Aβ) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.

KW - Alzheimer's disease

KW - Amyloid-beta

KW - Cholesterol

KW - LXR agonists

KW - Liver-X receptors

KW - Neurodegeneration

KW - Neuroinflammation

KW - Transgenic mouse models

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U2 - 10.2478/s13380-013-0136-z

DO - 10.2478/s13380-013-0136-z

M3 - Review article

AN - SCOPUS:84893022937

SN - 2081-3856

VL - 4

SP - 349

EP - 356

JO - Translational Neuroscience

JF - Translational Neuroscience

IS - 3

ER -

Pathogenesis, modulation, and therapy of alzheimer's disease: A perspective on roles of liver-x receptors

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Keywords

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