TY - JOUR
T1 - Pathogenesis and treatment options for chemotherapy-induced alopecia
T2 - a systematic review
AU - Rubio-Gonzalez, Belen
AU - Juhász, Margit
AU - Fortman, Jamie
AU - Mesinkovska, Natasha Atanaskova
N1 - Publisher Copyright:
© 2018 The International Society of Dermatology
PY - 2018/12
Y1 - 2018/12
N2 - Chemotherapy-induced alopecia (CIA) is one of the most troubling long-lasting side effects of cancer treatment. An estimated 65% of patients undergoing classic chemotherapy will experience hair loss, which is an extremely upsetting adverse event for many. CIA has been traditionally considered to be a diffuse, nonscarring alopecia; however, there are increasing reports of permanent hair loss post chemotherapy. Despite its large impact on patients, there are few proven treatments for CIA. Recent advancements in understanding the pathogenesis of hair loss are promising novel preventative and therapeutic strategies. Currently, scalp cooling during chemotherapy is the most effective preventive intervention with response rates ranging from 50 to 80%. To avoid patient morbidity, clinicians should be aware of the pathogenesis of CIA, characteristic patterns of hair loss associated with specific drug regimens, preventive measures that may be taken, and therapeutic options post chemotherapy. The following represents an updated systematic review of CIA, including characteristic clinical patterns, pathophysiology of the disease, therapeutic approaches, as well as a cost-effective analysis to assess the significance of this toxicity.
AB - Chemotherapy-induced alopecia (CIA) is one of the most troubling long-lasting side effects of cancer treatment. An estimated 65% of patients undergoing classic chemotherapy will experience hair loss, which is an extremely upsetting adverse event for many. CIA has been traditionally considered to be a diffuse, nonscarring alopecia; however, there are increasing reports of permanent hair loss post chemotherapy. Despite its large impact on patients, there are few proven treatments for CIA. Recent advancements in understanding the pathogenesis of hair loss are promising novel preventative and therapeutic strategies. Currently, scalp cooling during chemotherapy is the most effective preventive intervention with response rates ranging from 50 to 80%. To avoid patient morbidity, clinicians should be aware of the pathogenesis of CIA, characteristic patterns of hair loss associated with specific drug regimens, preventive measures that may be taken, and therapeutic options post chemotherapy. The following represents an updated systematic review of CIA, including characteristic clinical patterns, pathophysiology of the disease, therapeutic approaches, as well as a cost-effective analysis to assess the significance of this toxicity.
UR - http://www.scopus.com/inward/record.url?scp=85041110525&partnerID=8YFLogxK
U2 - 10.1111/ijd.13906
DO - 10.1111/ijd.13906
M3 - Review article
C2 - 29377091
AN - SCOPUS:85041110525
SN - 0011-9059
VL - 57
SP - 1417
EP - 1424
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 12
ER -