Patch-based surface morphometry feature selection with federated group lasso regression

Jianfeng Wu, Jie Zhang, Qingyang Li, Yi Su, Kewei Chen, Eric M. Reiman, Jie Wang, Natasha Lepore, Jieping Ye, Paul M. Thompson, Yalin Wang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Collectively, vast quantities of brain imaging data exist across hospitals and research institutions, providing valuable resources to study brain disorders such as Alzheimer’s disease (AD). However, in practice, putting all these distributed datasets into a centralized platform is infeasible due to patient privacy concerns, data restrictions and legal regulations. In this study, we propose a novel federated feature selection framework that can analyze the data at each individual institution without data-sharing or accessing private patient information. In this framework, we first propose a federated group lasso optimization method based on block coordinate descent. We employ stability selection to determine statistically significant features, by solving the group lasso problem with a sequence of regularization parameters. To accelerate the stability selection, we further propose a federated screening rule, which can identify and exclude the irrelevant features before solving the group lasso. Here, we use this framework for patch based feature selection on hippocampal morphometry. Shape is characterized through two different kinds of local measures, the radial distance and the surface area determined via tensor-based morphometry (TBM). The method is tested on 1,127 T1-weighted brain magnetic resonance images (MRI) of AD, mild cognitive impairment (MCI) and elderly control subjects, randomly assigned to five independent hypothetical institutions for testing purpose. We examine the association of MRI-based anatomical measures with general cognitive assessment and amyloid burden to identify the morphometry changes related to AD deterioration and plaque accumulation. Finally, we visualize the significance of the association on the hippocampal surfaces. Our experimental results successfully demonstrate the efficiency and effectiveness of our method.

Original languageEnglish
Title of host publication16th International Symposium on Medical Information Processing and Analysis
EditorsEduardo Romero, Natasha Lepore, Jorge Brieva, Marius Linguraru
ISBN (Electronic)9781510639911
StatePublished - 2020
Externally publishedYes
Event16th International Symposium on Medical Information Processing and Analysis 2020 - Lima, Virtual, Peru
Duration: 3 Oct 20204 Oct 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


Conference16th International Symposium on Medical Information Processing and Analysis 2020
CityLima, Virtual


  • Alzheimer’s Disease
  • Amyloid Burden
  • Feature Selection
  • Federated Learning
  • Group Lasso
  • Surface-Based Morphometry


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