Pas de deux of NLRP3 and ASC with CD63 on mast cell granules

J. Magarian Blander, Yuhua Shi

Research output: Contribution to journalArticlepeer-review

Abstract

Granulosomes are novel complexes that feature an unexpected partnership between the tetraspanin CD63 and the inflammasome proteins NLRP3 and ASC. Granulosomes assemble on mast cell granules to propel them along microtubules to the plasma membrane for degranulation.

Original languageEnglish
Pages (from-to)584-586
Number of pages3
JournalNature Immunology
Volume25
Issue number4
DOIs
StatePublished - Apr 2024
Externally publishedYes

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