Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity

Diana Moga; Patrick R. Hof; Prabhakar Vissavajjhala; Thomas M. Moran; John H. Morrison

doi:10.1016/S0891-0618(02)00012-1

Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity

Diana Moga, Patrick R. Hof, Prabhakar Vissavajjhala, Thomas M. Moran, John H. Morrison

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32 Scopus citations

Abstract

α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Journal of Chemical Neuroanatomy
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0891-0618(02)00012-1
State	Published - 2002

Keywords

Excitatory amino acids
GluR3
Interneurons

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title = "Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity",

abstract = "α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.",

keywords = "Excitatory amino acids, GluR3, Interneurons",

author = "Diana Moga and Hof, {Patrick R.} and Prabhakar Vissavajjhala and Moran, {Thomas M.} and Morrison, {John H.}",

note = "Funding Information: The authors thank W.G.M. Janssen and G. Andrews for expert technical assistance and A.P. Leonard for help with illustrations. This work was supported by NIH grants AG05138 and AG06647.",

year = "2002",

doi = "10.1016/S0891-0618(02)00012-1",

language = "English",

volume = "23",

pages = "249--253",

journal = "Journal of Chemical Neuroanatomy",

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T1 - Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity

AU - Moga, Diana

AU - Hof, Patrick R.

AU - Vissavajjhala, Prabhakar

AU - Moran, Thomas M.

AU - Morrison, John H.

N1 - Funding Information: The authors thank W.G.M. Janssen and G. Andrews for expert technical assistance and A.P. Leonard for help with illustrations. This work was supported by NIH grants AG05138 and AG06647.

PY - 2002

Y1 - 2002

N2 - α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.

AB - α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate excitatory neurotransmission in the central nervous system, and contain combinations of four subunits (GluR1-4). We developed a GluR3-specific monoclonal antibody and quantified the cellular distribution of GluR3 in rat hippocampus. GluR3 immunoreactivity was detected in all pyramidal neurons and most interneurons. In addition, we found a subset of parvalbumin (PV)-containing interneurons in the hippocampus and neocortex that was notable for its intense GluR3 immunoreactivity and lack of GluR2 immunoreactivity. Such an expression pattern of AMPA receptor subunits is likely to make these interneurons selectively vulnerable to excitotoxicity.

KW - Excitatory amino acids

KW - GluR3

KW - Interneurons

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IS - 4

ER -

Parvalbumin-containing interneurons in rat hippocampus have an AMPA receptor profile suggestive of vulnerability to excitotoxicity

Abstract

Keywords

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