Partners in crime: The role of tandem modules in gene transcription

Rajal Sharma, Ming Ming Zhou

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Histones and their modifications play an important role in the regulation of gene transcription. Numerous modifications, such as acetylation, phosphorylation, methylation, ubiquitination, and SUMOylation, have been described. These modifications almost always co-occur and thereby increase the combinatorial complexity of post-translational modification detection. The domains that recognize these histone modifications often occur in tandem in the context of larger proteins and complexes. The presence of multiple modifications can positively or negatively regulate the binding of these tandem domains, influencing downstream cellular function. Alternatively, these tandem domains can have novel functions from their independent parts. Here we summarize structural and functional information known about major tandem domains and their histone binding properties. An understanding of these interactions is key for the development of epigenetic therapy.

Original languageEnglish
Pages (from-to)1347-1359
Number of pages13
JournalProtein Science
Volume24
Issue number9
DOIs
StatePublished - 1 Sep 2015

Keywords

  • chromatin
  • gene transcription
  • histone
  • post-translational modifications
  • protein modular domains

Fingerprint

Dive into the research topics of 'Partners in crime: The role of tandem modules in gene transcription'. Together they form a unique fingerprint.

Cite this