Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

Vahram Haroutunian; Philip D. Kanof; Kenneth L. Davis

doi:10.1016/0006-8993(86)90179-4

Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

Vahram Haroutunian, Philip D. Kanof, Kenneth L. Davis

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Nerve growth factor (NGF) was injected into the lateral ventricle (5 μg on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.

Original language	English
Pages (from-to)	397-399
Number of pages	3
Journal	Brain Research
Volume	386
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(86)90179-4
State	Published - 29 Oct 1986

Keywords

Acetylcholinesterase
Choline acetyltransferase
Cortex
Ibotenic acid lesion
Nerve growth factor
Nucleus basalis
Rat

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10.1016/0006-8993(86)90179-4

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title = "Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor",

abstract = "Nerve growth factor (NGF) was injected into the lateral ventricle (5 μg on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.",

keywords = "Acetylcholinesterase, Choline acetyltransferase, Cortex, Ibotenic acid lesion, Nerve growth factor, Nucleus basalis, Rat",

author = "Vahram Haroutunian and Kanof, \{Philip D.\} and Davis, \{Kenneth L.\}",

year = "1986",

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AU - Haroutunian, Vahram

AU - Kanof, Philip D.

AU - Davis, Kenneth L.

PY - 1986/10/29

Y1 - 1986/10/29

N2 - Nerve growth factor (NGF) was injected into the lateral ventricle (5 μg on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.

AB - Nerve growth factor (NGF) was injected into the lateral ventricle (5 μg on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.

KW - Acetylcholinesterase

KW - Choline acetyltransferase

KW - Cortex

KW - Ibotenic acid lesion

KW - Nerve growth factor

KW - Nucleus basalis

KW - Rat

UR - https://www.scopus.com/pages/publications/0022970438

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SN - 0006-8993

VL - 386

SP - 397

EP - 399

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor

Abstract

Keywords

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